X-Men: Apocalypse is a very international film, with a villain from Egypt (Ancient Egypt, no less), key locations in Berlin and Poland, and of course many scenes at the X-Men's Westchester mansion. Like Captain America: Civil War before it, X-Men: Apocalypse opened in a number of international markets before coming to the U.S., including much of Europe and South America, which means that its box office will already have a strong head start by the time it hits U.S. theaters.
Starring James McAvoy, Michael Fassbender, Oscar Isaac, Nicholas Hoult, Evan Peters, Tye Sheridan, Kodi Smit-McPhee, Alexandra Shipp, Rose Byrne and Sophie Turner among its sprawling cast, X-Men: Apocalypse leaps forward another decade from X-Men: Days of Future Past and pits the X-Men against their greatest enemy yet: a godlike mutant called Apocalypse (Isaac). Though the critical reception hasn't been quite as enthused as that of the previous movie, Apocalypse is none the less doing a good job of conquering the world so far.
According to Deadline, X-Men: Apocalypse debuted to the tune of $103.3 million across 20,596 screens, and is #1 at the box office in 71 out the 75 markets it has released in so far. This is just a hair past the $100M opening weekend that X-Men: Days of Future Past scored in the same markets. Though it's possible that the movie's mixed reception (it currently has a Rotten Tomatoes score of 51%) may impact its domestic opening and lead to a higher than usual drop-off in subsequent weekends, it's clear that the X-Men brand still holds a lot of weight.
X-Men: Apocalypse closes out a trilogy of prequel movies that began with X-Men: First Class in 2011, which successfully got the main series back on track after 2006's much-maligned X-Men: The Last Stand. Since X-Men: Apocalypse director Bryan Singer's first movie adaptation of the X-Men comics in 2000, the series' continuity has gotten a little complicated, to say the least, but Apocalypse freshens things up by introducing new, younger versions of characters like Jean Grey (Turner), Nightcrawler (Smit-McPhee), Storm (Shipp) and Cyclops (Sheridan).
The movie's biggest competitors at the domestic box office next week will be Angry Birds and Neighbors 2: Sorority Rising, both in their second weekends, and Alice Through the Looking Glass, which will be making its debut. Alice in Wonderland topped $1 billion at the box office in 2010, so this may end up being a close fight for first place.
X-Men: Apocalypse opens in theaters May 27th, 2016, followed by Wolverine 3 on March 3rd, 2017, and unannounced X-Men films on October 6th, 2017 (possibly Gambit), January 12th, 2018 (possibly Deadpool 2), and July 13th, 2018. The New Mutants is also in development.