Even though Spider-Man was the first host fans ever saw Venom bond with, Marvel Comics definitely proved Peter Parker was never the best one. Despite how popular and famous Spider-Man's time with his black suit was, it was always destined to be a poor pairing.
It has become a common misconception that, due to his superpowers, Spider-Man was the perfect host for the Venom symbiote and Eddie Brock was just a rebound vessel to fuel the alien’s revenge. Many of the symbiote's early appearances hint at this, as the symbiote is obsessed with getting revenge on Peter Parker for rejecting it. Spider-Man even became darker than Venom in the alternate timeline of Spider's Shadow. However, in one comic issue that tackles the inner workings of Venom’s mind and lays every bit of information about the symbiote’s life functions in a literal format, it becomes clear that Spider-Man was never the perfect host he’s been made out to be.
In Venom: The End #1 by Adam Warren and Jeffrey Cruz, readers are given a look into a distant future of the Marvel Universe where Artificial Intelligence has taken over every corner of the universe with Venom being one of the only biological life forms alive. To survive, Venom used the codexes of every person the symbiote inhabited and recreated them, giving his own new-formed hive mind offspring hosts and giving himself an army he could use to fight the A.I. conquerors. While going through all of the prominent hosts Venom had possessed over the years, this comic gave each a star rating based on their level of compatibility with Venom. While Eddie Brock got five stars which indicated perfect symbiosis, Peter Parker only received a one-star rating. It was always assumed that the Venom symbiote loved being bonded with Spider-Man. Venom bonded with the closest human available to get revenge on Spider-Man, and that human happened to also hate Spider-Man just as much, fueling the anger and resentment. Based on this rating, however, it seems the symbiote was literally just angered by the rejection itself and not the fact that Spider-Man cut it off from its ‘perfect host’. Though Venom unleashed his ultimate (potentially Superman destroying) attack in this series, it's the compatibility ratings that are most revealing.
This rating system makes it seem as though Spider-Man wasn’t just ‘not perfect’, but an actively bad host. However, that may not completely be the case. When they were first bonded, Spider-Man and the Venom symbiote were inseparable as the black suit made Spider-Man stronger, faster, and overall a more powerful hero. Though once Spider-Man discovered that his suit was a living organism, he couldn’t take it and ripped it off of him for good. In that moment where Spider-Man decided to be rid of the symbiote once and for all, he chose to be incompatible with Venom, and given the violent and absolute nature of their separation, Spider-Man earned himself that one-star rating. While the comic never reveals it, it's tempting to wonder what Mr. Fantastic's rating would be given his unique symbiote transformation in Spider-Shadow.
At first Eddie Brock was just a means for Venom’s revenge, but when they decided to stay as one even after making up with Spider-Man, it became clear that their bond was over more than just a shared hatred, but one of true symbiosis, something Venom and Spider-Man never had.