Thankfully, when King Koopa (Dennis Hopper) tried to use the De-Evolution gun on Mario (Bob Hoskins), everybody’s favorite plumber used Luigi’s (John Leguizamo) mushroom to block the shot. Unfortunately for Anthony Scapelli, the gun worked moments earlier. When Koopa fired the weapon, missing a diving Mario, it struck Scapelli, turning him into a chimpanzee in a matter of seconds.
The gun is truly unlike any of other weapons on the list. While it doesn’t kill, its ability to turn the toughest human into a goofy chimpanzee is quite enough to fear.