I'm not even going to bring up Kirsten Dunst because honestly, no one cares.
So here's an idea, true-believer (sorry I couldn't help but unleash my inner Stan "The Man" Lee!) If you called the shots on Spider-Man 4, what would you do? Would you bring back Maguire, Raimi & Co. or flat-out replace them?
By the way, this is for everyone who wants to add their $.02: Readers and my fellow Screen Rant writers. So please, let's hear your ideas. And there will be a test on this later, boys and girls.
I'll go first (obviously, since I'm the schmuck who started this discussion).
Although I'm not the first to suggest him (IGN Filmforce), Edgar Wright (from Shaun of the Dead and Hot Fuzz) would be the perfect guy to take over for Sam Raimi. He's obviously talented in terms of visual flair (check out the action sequences from Hot Fuzz). Not to mention, he has the right comedic sensibilities - any and every thing involving Simon Pegg and Nick Frost together equals comic gold!
Heck, Wright could be the guy to give Webhead the classic wise-cracks we've been missing outta the previous films. If for no other reason, having him direct Spider-Man 4 could mean Pegg and Frost show up in some fashion. And the thought of them sharing a scene with Bruce Campbell is enough to make my head explode (in a good way).
As for Webhead himself, I'd love to say "Just get Tobey again!" But the truth of the matter is that Peter Parker is supposed to around 22-24 years old. By the time Spider-Man 4 graces the silver screen (summer 2010), Maguire will be 35. To be fair, if he can effectively play that age, then we're in good shape. But... there's too much fear of another "Roger Moore" situation (i.e. being so old that it becomes laughable and a distraction from said film).
With that in mind, I would say go for a flat-out unknown actor (in the vein of Chris Pine and Brandon Routh) and get him down for 3 Spidey adventures just to be safe.
For me, the villain is obvious: The Lizard. Dylan Baker (Fido) has been solid (albeit under-used) as Dr. Connors, and it'sabout time we get to see the Lizard roaming the sewers of Manhattan. If there has to be more than one villain in this film, I'd say go for Electro for no other reason than he's one of the all-time great classic Spidey villains.
Alrighty then. Who's next?