Call it wishful thinking about the whole "Venom is the villain in Spiderman 3" thing, but it looks like it ain't gonna happen. According to AICN, there is artwork all over the production offices of the upcoming Spidey flick indicating that the villain will be Sandman.
Realistically, this makes more sense than Venom from a marketing and box office standpoint. There are some things that are just creepy in drawn or animated form that would be scary as hell in live action, and Venom is one of them. When I think of that character in a live action film, for some reason Spawn comes to mind.
Sandman, if done right (and I have no doubt he will be), will make for a visually interesting villain and is much less intimidating for the kiddies, upon whom much bank will be made.