There are loads of manga series that feature protagonists who have trouble finding love, but Kiruru Kill Me takes this struggle to a whole other level in the most extreme manner imaginable.
The usual (and normal) way in which mangaka often depict these struggles is through bakadere character types who express their affections clumsily or shut-ins who suffer from acute social withdrawal. But Kiruru Kill Me's protagonist Aoi Nemo is neither of these things. He is a young prodigy with a medical license as well as a doctorate in biomedical engineering and immunology whose high intelligence and scientific prowess have granted him the ability to invent numerous medical products and technological innovations. His accomplishments are also renowned in the business world, leading to business magazines oftentimes featuring him on the cover of their publications.
During social events, many of which are held in his honor, Aoi appears charismatic and charming, able to strike up a conversation with relative ease and grace. His dashing good looks can even melt the hearts of the coldest tsundere's and put them into a stupor. But despite all of his accomplishments and social prowess, he is obsessed with his work to such a degree that he never made time for love. So when he falls hard for a girl named Kiruru Akaumi, Aoi doesn't recognize the strange and troubling phenomenon he's experiencing. His medical mind automatically calculates the possibilities from a scientific perspective by closely examining his odd symptoms (i.e. heart palpitations) that ail him to identify the diagnosis and, most importantly, his treatment.
When he finally diagnoses his condition as love, Aoi tries to find Kiruru, but when he does, he's stunningly unable to speak with her. He later decides to depend upon his ability to connect with others in business matters. So the advantageous youth utilizes his vast connections to learn her trade so that he can speak to her about business. But then Aoi hits another roadblock. She's an assassin. Without any connections in or knowledge of that particular field, the Aoi is once again forced to rely on his medical acumen and eventually concocts an utterly ridiculous plot. He will become Aoi's client and put a hit on himself. That way, she will initiate all of their interactions!
To help himself survive, Aoi fills a special medical room with cultures from his stem cells to create skin when necessary, blood bags, and multiple organs of different types that his body won't reject during a possible transplant to ensure his survival regardless of what she does to him. Of course, during their first encounter, he is so delusional that he actually views her attacks as sensual advancements and when he's left bleeding on the floor, views what transpired as a successful first date and can't wait until their next.
While a rather absurd and extreme premise, Kiruru Kill Me should be seen as a satirical take on characters with overly analytical minds who can't help but view the world in an emotionally detached way and who tackle their problems logically to a fault, especially when logic is the incorrect mythology. The manga also uses satire to deconstruct how people oftentimes fall back to what they understand when they confront the unknown and use that knowledge to help them comprehend it. This method is oftentimes ineffective as not everything is relatable, which is definitely the case here. And, of course, the manga explores the delusions of those who believe they are in a relationship with someone when they aren't and who misinterpret nonsexual actions as completely erotic. Nonetheless, Kiruru Kill Me is a perfect series for fans who enjoy romantic comedies with a ludicrous twist.