Kaguya Otsutsuki, also known as Princess Kaguya, is the main antagonist of the anime Naruto. Despite having appeared towards the very end of the anime series, she established herself as a force to be reckoned with, owing to dastardly evil schemes and an exhibition of insane god-like powers. She is also by far one of the most intelligent villains that the show has had, deftly manipulating events for many centuries.
To facilitate the foiling of her plans, it was necessary that Kaguya faced enemies who were close if not equal to her abilities. Irrespective of her short stint on Naruto, Kishimoto ensured that Kaguya gets to face some impressive opponents that allow her to establish her own abilities and powers. While some of these opponents were successful in defeating the tyrannical princess of the Otsutsuki clan, others were not so lucky.
Land Of Ancestors & Land Of That
Having arrived on Earth almost a millennium before the start of the main storyline, Kaguya and her clan wanted to harness the Chakra fruit from Earth’s God Tree. However, Kaguya developed a fondness for the planet and its people and, instead of destroying the planet, started to live amongst its people as the concubine of Tenji, the emperor of the Land of Ancestors.
When the Land of That threatened Kaguya over an ongoing border conflict, Kaguya went against Tenji’s explicit orders and attacked a representative from the Land of That. This resulted in her being excommunicated and hunted by both countries. Tired of human conflicts and heartbroken at Tenji’s betrayal, Kaguya fought them both using the Infinite Tsukuyomi, a power she awakened after consuming the Chakra Fruit.
Isshiki Otsutsuki
Kaguya came to Earth along with her partner Isshiki Otsutsuki. He was a high-ranking member of the clan and part of the main family. He also went on to become the leader of the secretive and powerful Kara. The original plan upon arrival on Earth was to sacrifice Kaguya to harvest the fruit from the Chakra Tree. However, Kaguya's fascination for the planet resulted in her turning against Isshiki and almost killing him in the ensuing confrontation.
Regardless, Isshiki was a higher-ranking member of the clan, and in that regard quite daunting as an Otsutsuki, Furthermore, he did not die from his battle against Kaguya in spite of the lower half of his body being completely destroyed. Capable of controlling the Kama, Isshiki has been described by Amado as capable of destroying entire planets if he can manage to harness the entirety of his power.
Sakura Haruno
Regardless of the many memes that surround Sakura Haruno, she is a talented medical ninja who has proven her skills time and again, eventually even surpassing her own sensei Lady Tsunade. While it is true that Kishimoto did not allow Sakura enough scope to truly reach her potential, her prowess as a ninja has never been underplayed.
Therefore, when Team 7 finally faces Kaguya Otsutsuki, Sakura Haruno undoubtedly becomes one of the toughest foes that the princess has had the chance to battle. In fact, it was her decisive punch that allowed Naruto and Sasuke to initiate the Chibaku Tensei, and seal Kaguya once and for all.
Obito Uchiha
Despite being a villain for the most part of the anime, Obito Uchiha redeemed himself towards the end by standing opposite Kaguya Otsutsuki and even sacrificing his own life to save the lives of his friend Kakashi and the protagonist of the show, Naruto. While he struggled as a ninja during his years as a child, Obito, under the tutelage of Madara Uchiha, developed into one of the strongest shinobis in the Ninja World.
Decked with immense intelligence, Obito could also easily harness the Mangekyo Sharingan, utilize Kamui, and even gain access to other dimensions if he focuses hard enough. This is how he was able to rescue Sasuke from the desert-dimension during the battle with Kaguya. He further has access to the Rinnegan, and he even completed a ten-tails jhinchuriki transformation, making him immensely powerful.
Kakashi Hatake
The sixth Hokage is undoubtedly one of the toughest opponents that Kaguya had to face. One of the brightest shinobis in the Ninja World, Kakashi had proved himself to be somewhat of a genius since an early age. His dexterity with almost every type of Jutsu owing to his copy-ability courtesy of his Sharingan, makes him further dangerous.
He is also one of the few non-Uchihas who could use the Sharingan with ease and perfection, even gaining access to the Mangekyo. After Obito grants him the use of both his Sharingan, Kakashi is also able to create a complete body Susanoo. Furthermore, it is a plan devised by him that finally defeats Kaguya.
Madara Uchiha
Although Kaguya and Madara do not face off against each other directly; it is Kaguya’s sinister plans and usurpation of Madara’s body that finally results in the revival of the Otsutsuki princess. The co-founder of Konohagakure, Madara was arguably one of the strongest, if not the strongest Uchiha to have ever existed.
He is immensely fluent with the use of chakra and possesses unparalleled expertise in ninjutsu, taijutsu, and genjutsu. He is also able to manifest a jhinchuriki transformation, has access to the Sharingan, as well as the Rinnegan, and finally the Rinne Sharingan, which allowed him to successfully perform the Infinite Tsukuyomi, a feat only Kaguya has successfully achieved previously.
Hamura Otsutsuki
One of the first two people capable of using chakra, Hamura Otsutsuki is immensely powerful and is one amongst the only four people who successfully defeated Kaguya Otsutsuki. Being the son of Kaguya, Hamura inherited chakra controlling abilities from his mother. However, upon realizing her true nature, he trained day-in-and-day-out with his brother to become strong enough to fight their mother.
He is someone who is an adept physical combatant and has access to the dojutsu Byakugan. He was further able to develop his Byakugan into the advanced Tenseigan while also being capable of destroying it. He also has access to Truth-Seeking Balls and could also utilize the Six Paths Senjutsu, a trait he used to seal the Ten-Tails transformation of Kaguya Otsutsuki.
Sasuke Uchiha
One of the most intelligent characters of Naruto, Sasuke Uchiha is immensely powerful and also one of the few people who were able to defeat Kaguya Otsutsuki. He is the reincarnation of Hagoromo’s son Indra and therefore possesses extremely powerful chakra, which is only made stronger with the strengthening of his Curse of Hatred.
A prolific user of the Sharingan, Sasuke even awakened the Eternal Mangekyo. He is also adept at using Nature Transformation, and also awakened the Rinneggan after Hagoromo gifted him half his chakra. The Rinnegan further allows him to have access to the various Six Paths Technique, which he ultimately uses with Naruto to seal Kaguya.
Naruto Uzumaki
Naruto is by far one of the toughest opponents that Kaguya has ever faced. Apart from his massive chakra reserves and jhinchuriki transformations, Naruto also happens to be the direct reincarnation of Hagoromo's younger son, Asura Otsutsuki.
After gaining half of Hagoromo’s chakra, Naruto is further able to wield the Six Paths Technique. His cunning and spontaneity in battle make him even more formidable, which is only enhanced by Naruto’s will, determination, and unflappable attitude. He along with Sasuke successfully defeats Kaguya at the end of the anime.
Hagoromo Otsutsuki
Undoubtedly the most formidable and toughest opponent that Kaguya faced was her own son Hagoromo Otsutsuki. The progenitor of the Six Paths Senjutsu, Hagoromo could combine the Yin and Yang chakras within himself and create mass from absolutely nothing. He was further attributed with powerful dojutsus like the Sharingan and Rinnegan and could use both without suffering any noticeable drawbacks.
His immense control over the Rinnegan provided him access to all the paths of the Six Paths Technique. He was also the person who created the initial version of ninjutsu, known as ninshu at the time. It was because of his chakra sharing abilities, that Naruto and Sasuke were finally able to defeat Kaguya for the second time, while it was him along with his brother Hamura, who defeated the Otsutsuki princess the first time around.