Visit the Ark
Mutant Year Zero: Road to Eden makes it easy to travel between levels, so players should take full advantage of this opportunity. Go to the Ark (the game's hub world of sorts) between every single or every couple of levels. Not only will players be treated to a short story from the Ark's Elder, but they will also have the ability to visit each of the shops housed in the neon city. Mutant Year Zero players should upgrade their weapons, purchase team abilities, and take a look at the wares of the shopkeeper, Iridia. She often has a new weapon for purchase, but if you can't afford that, then stock up on grenades and medkits. They're relatively cheap and players can carry as many as they want. In later fights, these items are necessary to survive.
Delta's upgrades are also very important to keeping guns relevant once players encounter harder enemies. Don't feel attached to any particular weapon as you will find better ones, but make sure to always equip attachments like scopes to improve the range and damage of your firearms.
Take Out High-Priority Targets First
After the player has set up in a solid position prior to combat, they should identify which enemies should be eliminated first. There are many different enemy types, from pyros that throw grenades, to stalkers that try to flank the heroes and land melee hits. To win the fight, knowing which enemies to prioritize is key. Take out healers and alerters first. Healers can revive dead squad mates or heal heavily damaged ones, and there is nothing worse than seeing all your hard work disappear with a well-placed medkit. Alerters will call in reinforcements, which is always a bad thing, so take them out before they can make a sound.
After those enemies are gone, most of the other enemies can be dealt with in any order, depending on the individual's playstyle. We'd recommend "putting down" the Zone Dogs fast, as they can move great distances and their bites hurt, then following that up by taking down grenadiers. Their area-of-effect and damage-over-time outputs can make the whole team wish for a re-do.
Use Grenades Effectively
Though Mutant Year Zero focuses on weapons and player abilities as the main tenants of its turn-based approach, there's a third element that is also key to winning battles: grenades. Each character can equip two grenades prior to a fight, so players should make sure they use these slots efficiently. Vary it with two different items, perhaps a Molotov and a grenade, or a grenade and a smoke bomb. Throw them when enemies are grouped up for maximum damage. And remember to keep a hold of those smoke bombs for when your heroes are affected by burn damage; it nullifies the effects.
Level Up and Equip
Last, but far from least, it's important to level up heroes and equip the best weapons and loot you have in your arsenal. Do this before every encounter, not just at the start of the level or after visiting the Ark. Players should always have at least one medkit and a few grenades before engaging a group of enemies.
Character abilities are also necessary for later fights, so make sure to spend XP wisely. Mutant Year Zero isn't generous with its points for abilities, so upgrade the characters to your playstyle, but remember your play-style should always incorporate stealth over pure firepower.