Whether you're on live television, or insulting a loved one, Ron Burgundy knows the answer is always saying the first thing that comes to mind - but be prepared to take some shots in return.
Or if you're Brick Tamland, just make sure you sell a half-baked insult with a condescending smile (and friend to back you up).
In Gran Torino, Clint Eastwood seems to do more damage with his mouth, than with his automatic weapons:
Kiss Kiss Bang Bang
It's the movie that helped get Robert Downey Jr. back into the spotlight, but it's co-star Val Kilmer who dishes out the best insults.
Almost every sentence out of Al Pacino's mouth sounds like a one-liner, but in Glengarry Glenross, he turned insults into an artform.
John Candy isn't known for a harsh temper, but most of us were too young to appreciate the brutal insult from Uncle Buck.
As Good As It Gets
Playing a famous author, Jack Nicholson showed why his character couldn't tell the difference between being clever, and insulting half the population of Earth.
Long before the Merc With the Mouth, Ryan Reynolds was taking on vampires with Blade's help - and delivering dozens of Deadpool-worthy lines along the way.
Even murderers have their limits - but if you really want to insult a fellow inmate, get as disgusting and relatable as possible: "For me, you're somewhere between a cockroach and that white stuff that accumulates at the corner of your mouth when you're really thirsty."
Hardened criminals or foul-mouthed men don't have anything on the teenage girls in this classic, with lines that still make us wince.
Sometimes, an insult is just for the audience to enjoy - and repeat to themselves, and their friends, for the rest of their lives.
There are classic insults, and then there are the ones we'll never be able to deliver like the stars - but we can dream, Mr. Costner.
Two heads are better than one, and if duo dissing was an Olympic sport, there's no question Bill Murray and Dan Akroyd take home the gold.
You can insult people by disrespecting all they stand for, or just by being clever. But if you're Mark Wahlberg, why not do both at the same time?
Garth may not get much credit for his brains, but Wayne's World saw him deliver one of the most polished movie metaphors we've ever heard.
Deadpool is one anti hero who is not afraid to shoot you in the head - or cut down some of the most well-known X-Men with some truly choice words: "If I ever decide to become a crime-fighting shit swizzler, who rooms with a bunch of other little whiners at Neverland Mansion with some creepy, old, bald, Heaven’s Gate-looking motherfucker… on that day, I’ll send your shiny, happy ass a friend request."