Tom Holland (The Impossible) will make his big screen debut as Peter Parker/Spider-Man in the Marvel Cinematic Universe in the upcoming Captain America: Civil War, having already been revealed ahead of time as part of the Civil War trailer marketing. The character will headline his own MCU solo movie in 2017, under the direction of Jon Watts (Cop Car); as far as story details go, however, specific information on the Spider-Man movie reboot remain under wraps for the time being. That includes which villains and/or fellow Marvel superheroes will be written into the film by screenwriting duo John Francis Daley and Jonathan M. Goldstein (Horrible Bosses, Vacation).
Similarly, the 2017 Spider-Man solo movie has yet to gain an official title, though The Spectacular Spider-Man and Spider-Man: The New Avenger have been among the more popular rumored possibilities reported to date. The latest rumored title we can add to the list is Spider-Man: Homecoming, though the implications of that particular subtitle are perhaps more interesting that the full title itself, where it concerns which specific Marvel comic books will be adapted by the film.
The BBC (via Empire) has noted that Sony Pictures - which, lest we forget, is now sharing the Spider-Man movie rights with Marvel Studios - has registered the URL SpiderManHomecomingTheMovie.com, suggesting that Spider-Man: Homecoming could in fact be the title of Marvel's upcoming film reboot. Of course, this is no way guarantees that Homecoming will be part of the full title for the 2017 Spider-Man solo movie. After all, Warner Bros. Pictures registered multiple URLs ahead of announcing the title for Batman V Superman: Dawn of Justice, yet none of them even remotely matched up with the movie's proper name. That could end up being the case here too, but that doesn't preclude the possibility that the film will take some cues from the "Homecoming" comic book storyline all the same.
"Homecoming" is the title of The Amazing Spider-Man issue #252 that was written by Tom DeFalco and illustrated by Ron Frenz. The storyline revolves around Peter Parker's Spidey returning to his stomping grounds in New York City, after having gained his Venom alien symbiote costume following the 1984 Secret Wars comic book event. It is fair to assume that the 2017 Spider-Man solo movie will not feature Peter wearing his Venom costume (especially given that Sony is now moving ahead with a solo Venom movie reported to be separate from the MCU), but the general premise of "Homecoming" could be carried over into Watts' film; that is, Peter will get a new costume and return to fighting crime in New York, after the conclusion of the MCU's Civil War (read: the MCU equivalent of a comic book "event").
The "Homecoming" storyline also features special appearances by such Avengers as Captain America and Iron Man (played by Chris Evans and Robert Downey Jr. in the MCU), the latter of whom looks to be a mentor to Holland's Peter Parker in the MCU - and thus, potentially the one who provides Spidey with an upgraded costume somewhere along the way in Civil War (maybe even the one shown in the film's second trailer). There are other major superheroes who make an appearance in "Homecoming" - including such established MCU players as Hawkeye (Jeremy Renner) and The Wasp (Evagenline Lilly) - but it's likewise safe to assume that if any of them do show up in the 2017 Spider-Man film, it will be as a cameo and nothing more.
Last, but not least, both Dr. Curt Connors/The Lizard and Felicia Hardy show up in the "Homecoming" comic book story. Marvel President of Production Kevin Feige has indicated before that the 2017 Spider-Man film will feature a super-villain not seen in any previous Spider-Man live-action movie, so that would disclude Dr. Connors' transformed alter ego from showing up. However, one of the fan theories about Zendaya's mystery character in the movie is that she's actually Felicia Hardy and will start off the film as just one of Peter's fellow high schoolers, before adapting her Black Cat moniker (either in the 2017 film or a future Spider-Man movie). It's not impossible either, as we have yet to see Black Cat proper in a live-action Spider-Man film.
Captain America: Civil War will release on May 6, 2016, followed by Doctor Strange– November 4, 2016; Guardians of the Galaxy 2 – May 5, 2017; Spider-Man – July 7, 2017; Thor: Ragnarok – November 3, 2017; Black Panther – February 16, 2018; The Avengers: Infinity War Part 1 – May 4, 2018; Ant-Man and the Wasp – July 6, 2018; Captain Marvel – March 8, 2019; The Avengers: Infinity War Part 2 – May 3, 2019; Inhumans – July 12, 2019; and as-yet untitled Marvel movies on May 1, July 10 and November 6, 2020.