Spider-Man is, by definition, the friendly neighborhood hero, who has a warm personality that generally connects with everyone he encounters in his adventures. Over the years, that's grown to include some unlikely people. Spider-Man has developed some very unique friendships, with allies and enemies alike.

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Peter Parker's ability to connect to other people never wavers. In the face of insurmountable odds or heartbreaking deaths, he always manages to find a buddy or worthy ally with just about anyone in the Marvel Universe. Some of his partnerships in the comics are truly unexpected, reaching beyond the page into stage and screen.

Spider-Man & Iron Man

Iron Man unmasks Spider-Man as Peter Parker during Civil War

Spider-Man and Iron Man's mentor and mentee relationship in the MCU has led to a lot of funny memes. In the comics, it hasn't always been a laugh riot. They actually didn't even meet until over a decade after both were introduced in the comics (in Marvel Team-Up #9 in 1973).

Their relationship for most of Marvel history has been one of professional courtesy and respect, and they did become close, especially on the eve of the Civil War event. But they fell out after Spidey switched sides and joined Captain America in the fight against registering superheroes.

Spider-Man & Scarlet Spider

Spider-Man Peter Parker meets Ben Reilly the Scarlet Spider Marvel Clone Saga

These days, Spider-Man is very familiar with the concept of alternate versions of himself, thanks to the multiverse complexity of Spider-Man: Into The Spider-Verse. In the 90s, he was much less so, which is why the idea of a clone of himself called the Scarlet Spider was such a hard thing to accept.

Ben Reilly was part of the interminable Clone Saga, a sprawling, confusing storyline that the MCU should avoid adapting, and he and Peter were initially at odds over who was the real Wall-Crawler. The two eventually grew to accept and even like one another.

Spider-Man & Doctor Strange

Spider-Man, Doctor Strange, and Scarlet Witch battle demons in Marvel Comics.

Doctor Strange will appear in Spider-Man: No Way Home, perhaps filling the mentor role Tony Stark once played. That's an unlikely role for Strange in the MCU but not entirely unreflective of the comics. The two have very little in common, with Strange being a mystical man of means and Peter being an otherwise regular kid (except for his powers).

But from their first meeting in Spider-Man Annual #2 in 1965, they develop trust and admiration for each other. Though Peter is often a fish out of water in all things magic, he always relies on Doctor Strange, and Strange has always been there from the start, offering guidance where he can.

Spider-Man & Loki

Spider-Man teams up with Loki

Spider-Man and Loki have yet to meet in the MCU, but if they ever do, it might play out as unexpectedly as their relationship in the comics. Loki is one of the greatest magicians in Marvel Comics and an avowed trickster, but his respect for Spider-Man seems to be sincere.

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In the Chasing A Dark Shadow storyline from 2004, Spider-Man goes looking for Strange for help with a sorceress named Morwen. But Loki is standing in as the Sorcerer Supreme. Nevertheless, the two hit it off, and end up sharing a hot dog on the roof of the Sanctum Santorum.

Spider-Man & Flash Thompson

Spider-Man Peter Parker finds out that Flash Thompson is Agent Venom Marvel

Spider-Man: Far From Home was partly based on classic teenage comedies and their tropes, which included the school bully. In the comics and in the movies, that's Flash Thompson. The two men were oil and water for decades, and it wasn't until Thompson became a hero of sorts himself - Agent Anti-Venom, a militaristic version of the alien symbiote - that the two become friends. Flash realizes that Spider-Man is Peter Parker and their relationship makes a huge evolutionary leap in terms of respect.

Spider-Man & Superman

Spider-Man fighting Superman

Spider-Man and Superman are unlikely friends, mostly because they exist in separate universes. They have crossed over on a few occasions over the years, including the first-ever cross-company superhero crossover, Superman Vs. the Amazing Spider-Man: The Battle Of The Century in 1976.

Though they are supposed to be fighting each other, the two quickly team up to stop a deadly plot by Lex Luthor and perennial Spider-Man villain Doctor Octopus. The optimism and sense of justice both Spider-Man and Superman possess made them fast friends.

Spider-Man & Wolverine

Wolverine Spider-Man Fist Bump

Spider-Man and Wolverine are two very different people, with Spider-Man being a young, jovial, and quippy type and Wolverine a brooding quiet loner. The two make no sense as friends or teammates, but they've been both.

They squared off in Spider-Man Vs. Wolverine in 1987, and were later teammates on the New Avengers line-up in the early 2000s. Spider-Man's sense of humor eventually won Logan over, and they developed a snarky shorthand that is a lot of fun for readers.

Spider-Man & Venom

Spider-Man shaking hands with Venom

One of the most unlikely friendships Spider-Man has is with one of his greatest villains, Venom. They two started off as bitter enemies when the alien symbiote that had bonded with Peter Parker then attached itself to Eddie Brock (making him Venom). But Venom became an anti-hero in the 90s, and their relationship morphed.

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Venom did a lot of bad things, but they teamed up to take down Carnage or when the symbiote was bonded to Flash Thompson, the dynamic continued to evolve. While they wouldn't be considered the best of friends, they arrived with a sense of mutual respect hard to imagine in the beginning.

Spider-Man & Deadpool

Deadpool and Spider-Man sit on a roof together

At first, Spider-Man and Deadpool seem a very unlikely friendship given how meta Deadpool tends to be. But the two are actually very similar. Deadpool's personality isn't too far removed from Peter Parker's in terms of always being ready with the one-liners. Deadpool co-creator Rob Liefeld has also acknowledged he based the Deadpool costume on Spider-Man.

The two heroes became pals in the first meeting back in 2006, and remain close, despite Deadpool trying to kill Spidey, more than once. In fact, Spider-Man: No Way Home might be a good place to introduce Deadpool to the MCU if the multiverse rumors pan out.

Spider-Man & The Cast Of SNL

Spider-Man SNL Cast Marvel Team-Up

One of the strangest but most entertaining friendships Spider-Man has developed in the comics is with the classic inaugural cast of Saturday Night Live. The two teamed up in a comic in the late 70s, in Marvel Team-Up #74, written by Chris Claremont and drawn by Bob Hall. Spider-Man has to defend the cast from some thugs when he and Mary Jane Watson attend an episode. Many classic SNL vets are featured, including Gilda Radner, John Belushi, Dan Ackroyd, Garret Morris, and Bill Murray.

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