After big multiverse altering projects like Loki, Spider-Man: No Way Home and Doctor Strange in the Multiverse of Madness, Marvel Studios has returned to street-level heroes with Ms. Marvel now streaming on Disney+. While the stakes aren't as high, Kevin Feige has been actively teasing big things to come.
He went on to say, via Complex, "I think there have been many clues already, that are at least apparent to me, of where this whole saga is going. But we’ll be a little more direct about that in the coming months, to set a plan, so audiences who want to see the bigger picture can see a tiny, tiny, tiny bit more of the roadmap." The only way to go bigger than Thanos would be to adapt Galactus, but is Galactus truly the biggest threat in all of Marvel?
Professor X
After an exciting return in Multiverse of Madness, fans continue to theorize when Professor X will turn up again in the MCU. While the limitations of paralysis are definitely a physical constraint for Charles Xavier, he still has the most powerful mind in the entire universe.
From his sheer telekinetic strength, Professor X could easily take down Galactus with the help of the X-Men. Hopefully more mutants are introduced into the MCU, as the X-Men will definitely need to be around to deal with the threat of Galactus.
Grandmaster
The full extent of the Grandmaster's abilities remains to be seen in the MCU. All viewers know is that he is immortal and that seems to be it. In the comics, however, Grandmaster is easily one of the most powerful beings.
Alive since the creation of the universe, the Grandmaster is able to control the radiation from the Big Bang which can allow him to manipulate and use the universe's energies as power. He is also a true immortal, as he cannot die through any possible means. While usually portrayed as a villain, Grandmaster's abilities would certainly come in handy when facing the fearsome Galactus.
Captain Marvel
Considered by many to be one of the most over-powered superheroes of all time, Carol Danvers easily held her own against Thanos in Endgame. Armed with the powerful energy of the Tesseract, Captain Marvel has been shown to destroy entire spaceships effortlessly.
While her comics counterpart isn't anywhere near as powerful as Galactus, the MCU version easily stands as one of the strongest, which makes her a very useful ally.
Skaar
Yet to be introduced into the MCU, Skaar is rumored to soon feature in She-Hulk, according to CBR. His comic counterpart is easily one of the most powerful characters in the Marvel Universe. Skaar's strength and healing rivals that of both his father, the Hulk, and that of Wolverine.
The super-powered character is also able punch people miles away. His strongest attribute, though, has to be the "Old Power". This ability allows Skaar to absorb the energy of entire cities and even control the different elements of the Earth. Skaar could easily defeat Galactus.
Thanos (With Infinity Gauntlet)
Armed with the Infinity Gauntlet, Thanos is literally unstoppable. Thanos has easily shown some of the biggest displays of power in the MCU, especially when he was able to send a moon crashing down on Titan against a sect of the Avengers in Infinity War.
With just the flick of a finger, Thanos could make Galactus disappear in an instant. With the might of all the Infinity Stones and his natural strength, Thanos is nearly unstoppable, and arguably no single hero or villain in the Marvel world could defeat him alone.
Franklin Richards
Already hinted at in Doctor Strange 2 with the mention of Reed Richards' kids, Franklin Richards is the son of Fantastic 4 heroes Mr. Fantastic and the Invisible Woman. Richards is one of the most powerful beings in the comics. He is able to create anything into existence just from one thought.
He had even gone so far as to subconsciously make a pocket universe. With his abilities, Franklin could theoretically make Galactus cease to exist with a single thought. In Heroes Reborn #4, he was considered to be so powerful that he was described as a "being whom the Celestials felt was on par with themselves".
Scarlet Witch
While her fate following Multiverse of Madness remains unknown, it definitely won't be the last time fans see her, there are so many more stories in the MCU that would benefit having Wanda. Many would also like to see the Scarlet Witch redeem herself in some way.
With her reality-warping powers thanks to chaos magic, Maximoff would undoubtedly make a worthy adversary to Galactus. Just with her saying "No More Mutants" in the House of M comic event, she was able depower nearly all mutants throughout the Multiverse. As a Multiversal Nexus being, she could easily tear apart Galactus.
Odin
Sadly fans were never treated to seeing Odin's full might in the MCU. With the character killed off during Ragnarok, it's unlikely the character will return again, but in comics, Odin is a completely different breed of God.
With the "Odinforce", Odin is able to fully stop time, move planets, fully destroy galaxies and transport others through the multiverse in addition to his main power set, which includes super strength and durability. In order to truly beat Galactus, Odin would also benefit from using his excellent tactical skills to catch the Planet Eater when he least expects it.
The Living Tribunal
Initially set to make an appearance in Infinity War, The Living Tribunal is a cosmic entity that protects threats from the Multiverse, serving as a judge for all realities. He made his first appearance as a statue that was pruned by the TVA in Loki followed by a full-fledged introduction in Doctor Strange 2, as he watches Doctor Strange and America Chavez go through various universes.
Created by the One Above All, The Living Tribunal is the living embodiment of the entire Marvel Multiverse, and as such, his powers are beyond comprehension. It is however said that he could destroy the Infinity Stones with a single thought. Therefore, he could easily defeat Galactus.
The One Above All
The One Above All is the omniscient figure who created the entire Multiverse, and ergo he is the most powerful being of all. He is the version of God that exists in the Marvel Universe. Theories have also run rampant that The Presence from DC and The One Above All are the same entity, as the Marvel and DC universes exist within the same multiverse.
No matter what, there is nothing that can beat the One Above All, hence the name. The day that he debuts in the MCU, it will rock the whole world. While he would never interfere with Galactus' affairs, he could easily beat him.