The first time it was revealed that Warren Ellis' Extremis story line would be used for the plot and conflicts of Iron Man 3, we were elated. Hailed as one of the best Iron Man stories to date, its emphasis on Tony Stark's evolving perception of what his powers really are, and how a human being so inextricably linked to technology can develop a sense of identity. From the trailer, the journey looks every bit as trying and addictive as it was in the comics.
Tony fusing his body with the Extremis nanovirus (he is seen going in for the procedure in the trailer as well) will obviously be an important element of the film, even if Guy Pearce maintains his role as Aldrich Killian is simply "cameo stuff." Clearly the procedure will work its way into Tony's personal life.
Whether the armor components next to the bed are a sign that Tony can't feel at ease without his armor close enough to immediately suit up, or that he's obsessed with perfecting his creation, expect to see a more frayed and fragile Stark this time around.