WandaVision is a loving tribute to television sitcoms. Several vintage TV sitcoms are referenced in the series, but for as many nods as the show has to television, there are equally as many to the original Marvel comic books. Several major Marvel storylines are very apparent in the DNA of the series so far.
The series is layered with important MCU Easter eggs and references, but the most critical might be from the comics. The tragic story of Wanda Maximoff and Vision appears to be playing out in large measure just as it did on the page.
Young Avengers
The Young Avengers is a relatively recent superhero team from Marvel Comics, but one with major connections to Vision and Scarlet Witch. Two of the young team's original members, Wiccan and Speed, are actually Wanda and Vision's grown children, William and Thomas. Their existence is complicated - these versions are not the originals, but the reincarnated souls of her children. The complicated story involves Mephisto, the devil-like being who may be playing a role in WandaVision. The MCU also seems to be building toward the Young Avengers.
Scarlet Witch (2015)
A recent comic book that may end up playing a big role in the outcome of WandaVision is the 2015 comic book series by writer James Robinson and a variety of artists, including Vanesa Del Rey, Marco Rudy, Chris Visions, and Steve Dillon. This series was more in a classic horror vein, with Scarlet Witch investigating paranormal crimes alongside her mentor, Agatha Harkness. This is key because Agatha Harkness, in the form of Agnes, might be playing a major role in the television series.
Giant-Size Avengers #4
The series is in many ways about the domestic lives of Wanda and Vision. Many of their milestones are taken directly from the comics. Wanda and Vision are already married at the beginning of the television show, but their wedding in the comics was a major event with possible implications for the MCU.
Scarlet Witch is imprisoned by Dormammu, the villain of the first Doctor Strange movie, and Vision must free her. The issue ends with their wedding. Wanda will be playing a key role in the upcoming Doctor Strange In The Multiverse Of Madness. Dormammu could be just one MCU villain even stronger than Thanos in Phase 4.
Heroes Reborn
Heroes Reborn is generally a part of Marvel history fans wants to forget. In the mid-90s, with sales and creative directions floundering on their core titles of the Avengers and Fantastic Four. Marvel outsourced both to Image founders Rob Liefeld and Jim Lee respectively. It was a bust but involves an idea that could be key in WandaVision.
The teams are rebooted by being teleported to a pocket universe created by Franklin Richards, the son of Reed and Sue from the Fantastic Four. This bubble universe bears some similarities to that of Westview, and there is a fairly significant Fantastic Four allusion within WandaVision.
Vision Quest
The "Vision Quest" story in West Coast Avengers #42–45 from 1989 by legendary comic book writer and penciler John Byrne could have some bearing on where the series is ultimately going. In the arc, Vision's memory and human brain patterns are wiped out by time-traveling villains. He loses his marriage to Wanda and most critically, it's revealed in this story that their children Thomas and William are not real, but fantasies derived from fragments of Mephisto's soul.
The Vision And Scarlet Witch (1982)
The classic Marvel couple has been the subject of two major limited series in the comics. The first, from 1982, was written by Bill Mantlo and penciled by Rick Leonardi. This series is very significant since it's here that Magneto is retconned as the father of Scarlet Witch and Quicksilver, her twin brother.
Quicksilver is a major part of her life and the trauma she's trying to avoid in Westview. Quicksilver could potentially return to the MCU as a result of the series, and Wanda's origin could potentially change as well now that the rights issues dividing the characters between Fox and Disney have been resolved.
The Vision And Scarlet Witch (1985)
WandaVision is full of Easter eggs and references to both the comic books and the Marvel Cinematic Universe. Some of its most important moments and images come directly from the 1985 Vision And The Scarlet Witch mini-series, written by Steve Englehart with art by Richard Howell. This series sees the unusual conception of their children, as well as their attempts at a normal, domestic life. The Halloween scene glimpsed in teasers for the series also has its origins in this comic book.
Avengers: Disassembled
Wanda's history in the comics has largely been one of grief and trauma for many years. The modern foundation of that really begins in Avengers: Disassembled. This 2004 crossover event by numerous writers, including Brian Michael Bendis and Robert Kirkman, saw Wanda lose control of her powers and try to destroy the Avengers.
Wanda goes so far as to summon a Kree army to attack the world. In the battle, Hawkeye is killed. Numerous MCU characters could return in Hawkeye's Disney+ series. It's possible that Scarlet Witch will be one of them, given her relationship with Clint in the movies.
The Visions
The comic book series with the most immediate influence on the show might be The Visions, from writer Tom King and artist Gabriel Hernandez Walta. In this 12-issue limited series, Vision attempts an attempt at domestic life in the Washington D.C. suburbs by creating synthezoid versions of a new wife and children. The comic has no real connection to the show in terms of plot, but the themes inherent in both are very similar, as both Vision and Wanda respectively seek a kind of normal, happy life.
House Of M
The comic book most often referred to in connection to WandaVision is House Of M. This series is one of the epochal comic book events of the 21st century. Growing out of Avengers: Disassembled and the cumulative grief of Wanda's entire life, Wanda goes mad with grief and changes reality so her children exist again.
When this fails, she turns against her family and people, and with three simple words - "No more mutants" - erases 90% of the mutant population in the Marvel universe. The event has major ramifications in the comics to this day. One theory has Phase 4 of the MCU being essentially the House Of M, but in reverse, creating mutants instead.