House may be remembered for its misanthropic, brilliant protagonist, Dr. Gregory House (Hugh Laurie), but the medical drama had a cast full of gifted actors. On the show, House leads a team of diagnosticians at the fictional Princeton-Plainsborough Teaching Hospital. In addition to fighting to save his patients and battling a pain medication addiction, Dr. House faces conflict with other doctors, including those on his own team. House's outside-the-box thinking causes him to take risks when treating his patients, and sometimes this includes flagrantly breaking hospital rules. But as a medical genius, he's right more often than not.
In its run from 2004-2012, House was nominated for 169 awards. With 14 wins, Laurie managed to add charm and humor to a character with no bedside manner. And while Laurie made Gregory House popular, the character also benefitted from being modeled after one of literature's greatest detectives, Sherlock Holmes. Creator David Shore is a fan of the Baker Street sleuth, and references to Sherlock Holmes are present throughout House, including Dr. James Wilson (Robert Sean Leonard), House's closest confidant, being a stand-in for Dr. John Watson. With its unique stories and literary background, Laurie and Leonard are joined by a talented cast on the medical drama.
Hugh Laurie As Dr. Gregory House
Laurie plays Dr. Gregory House, the titular curmudgeonly doctor with the brilliant medical mind, in the House cast. Even as House is behaving miserably, it's difficult not to laugh at his wit, which Laurie gives the character in spades. Laurie's background is in comedy, getting his start as one half of the British comedy duo Fry & Laurie alongside Stephen Fry. Though the medical drama is by far the actor's most well-known work, Laurie received critical acclaim after House for playing Richard Onslow Roper in miniseries The Night Manager. Laurie also starred in two Armando Iannucci series, as Tom James in Veep and as Ryan Clark in Avenue 5.
Robert Sean Leonard As Dr. James Wilson
Wilson plays Dr. James Wilson in the House cast. The kind-hearted Wilson is House's only real friend and head of the Department of Oncology at PPTH. In addition to House, Leonard is best known for his earlier work, as Peter Müller in Swing Kids and, most famously, Neil Perry, the prep school senior who restarted the titular club in Dead Poets Society. In addition to his screenwork, Leonard is a gifted theatre actor and three-time Tony Award nominee. He won Best Featured Actor in a Play for his role as A.E. Housman in The Invention of Love.
Omar Epps As Dr. Eric Foreman
Dr. Eric Foreman is played by Omar Epps in the House cast. Dr. Foreman is a neurologist who, like House, can be blunt to the point of rudeness, though his personality softens in later seasons. An actor and rapper, Epps earned acclaim and awards nominations for his role as Quincy McCall in the film Love & Basketball. On the TV side, Epps played another doctor, Dr. Dennis Grant, on E.R. Epps' other television roles include Darnell Hodges in This Is Us and Detective Malcolm Howard in Power Book III: Raising Kanan.
Jesse Spencer As Dr. Robert Chase
Jesse Spencer plays Dr. Robert Chase, a surgeon and intensive care specialist, in House. Dr. Chase's admiration of House makes him appear sycophantic, and he's often underestimated, though he too has a brilliant diagnostical mind. Spencer's first major acting role was as Billy Kennedy on Australian soap opera Neighbours. The actor would go on to star as Lieutenant Mattew Casey in Chicago Fire, a role he reprised in the franchise's other series, Chicago P.D. and Chicago Med.
Lisa Edelstein As Dr. Lisa Cuddy
Lisa Edelstein plays Dr. Lisa Cuddy in the House cast. Dr. Cuddy is Dean of Medicine and Chief Hospital Administrator, and House's boss. She and House frequently clash, but they have an understanding for one another, and share sexual tension throughout the series. Edelstein is best known for playing Lisa Cuddy, but she also led the Bravo series Girlfriends' Guide to Divorce, playing self-help book author protagonist Abby McCarthy.
Jennifer Morrison As Dr. Allison Cameron
Jennifer Morrison plays Dr. Allison Cameron, an immunologist and the youngest member of House's diagnostician team. Morrison is best known for playing Emma Swan in fantasy series Once Upon a Time. The actress's other notable roles include Ted Mosby's love interest Zoey Pierson in How I Met Your Mother and Winona Kirk, Captain Kirk's mother, in the Star Trek movie franchise.
Peter Jacobson As Dr. Chris Taub
Amongst the House cast is Peter Jacobson as Dr. Chris Taub, a plastic surgeon who joins House's diagnostician team. Interestingly, Taub and House co-star Edelstein had bit parts together in As Good As It Gets, playing a couple at a restaurant. Haub's other credits of note include playing Proxy Alan Snyder in Colony and Agent Wolfe in The Americans.
Olivia Wilde As Dr. Remy "Thirteen" Hadley"
Dr. Remy, an internist and member of the diagnostician team, is played by Olivia Wilde in the House cast. Prior to House, Wilde's TV credits included The O.C. as Alex Kelly and The Black Donnellys as Jenny Reilly. Since House, Wilde has appeared in blockbuster movies like TRON: Legacy as Quorra and Cowboys & Aliens as Ella Swenson along with indies like Drinking Buddies as Kate. Wilde is also a director, having helmed Booksmart and Don't Worry Darling, playing Bunny in the latter.
House Supporting Cast & Characters
Kal Penn as Dr. Lawrence Kutner - Kal Penn played Dr. Lawrence Kutner, a sports medicine doctor and diagnostician team member in House. Kutner was killed off House early because Penn accepted the position of Principle Associate Editor in the White House Office of Public Engagement under the Obama administration. As an actor, Penn is best known for playing Kumar Patel in the Harold & Kumar movie franchise.
Amber Tamblyn as Dr. Martha Masters - Amber Tamblyn plays med student Dr. Martha Masters in the House cast. Tamblyn is best known for playing Tibby Rollins in the Sisterhood of the Travelling Pants film franchise, the title protagonist in family drama series Joan of Arcadia, and Charlie Harper's long-lost daughter Jenny in Two and a Half Men.
Odette Annabale as Dr. Jessica Adams - Dr. Jessica Adams is a prison doctor and the last member of House's diagnostician team, and she's played by Odette Annabale. Annabale's most famous roles include Beth McIntyre in Cloverfield and Samantha Arias/Reign in the Arrowverse's Supergirl.
Charlyne Yi as Dr. Chi Park - Charlene Yi plays Dr. Chi Park, a neurologist, in the House cast. They are best known for playing Jodi in both Knocked Up and This Is 40.
Sela Ward as Stacy Warner - Stacy Warner, House's ex-girlfriend, is played by Sela Ward. Ward has won two Emmys, for her roles as Teddy Reed in Sisters and Lily Manning in Once and Again.
David Morse as Michael Tritter - David Morse plays Michael Tritter, a police detective with a grudge against House, in the House cast. Morse's breakout role was as Dr. Jack Morrison in St. Elsewhere, another medical drama. In film, he's known for playing corrections officer Brutus "Brutal" Howell in The Green Mile and sketchy neighbor Robert Turner in Disturbia.
Edi Gathegi as Jeffrey Cole - Medical geneticist Jeffrey Cole is played by Edi Gathegi. Gathegi starred as Laurent in the first two Twilight movies and has a recurring role as Matias Solomon in The Blacklist.
Andy Comeau as Travis Brennan - Andy Comeau plays Travis Brennan, an epidemiologist, in House. The actor is best known for playing Teddy Hofftsodt in Huff.
Carmen Argenziano as Henry Dobson - Carmen Argenziano is a former medical school admissions officer, and he's played by Henry Dobson. Argenziano has had a prolific acting career, and his best-known role is General Jacob Carter in Stargate SG-1.
Anne Dudek as Amber Volakis - Anne Dudek plays Amber Volakis, an interventional radiologist, in the House cast. Dudek's other notable television credits include playing Francine Hanson in Mad Men and Danielle Brooks in Covert Affairs.