Before we begin this list, let's break down one of the true elements of Grey's Anatomy. These doctors save lives on a daily basis and will give us an occasional laugh and some tears along the way. But what sets Grey's apart from most shows are the unions. Not the friendships, but the love triangles, the breakups, the getting to-know-one-anothers, and the long-lasting connections that some share.

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Thinking back to the beginning of Grey's Anatomy, there have been numerous hookups, one night stands, and missed chances. But what makes the essence of the show are the true romances. Now, a hookup is not considered a romance. A romance is something that had to have some legs to it and a pretty good storyline. The doctors at Grey Sloan Memorial Hospital are good for those one-week relationships, but the really juicy stuff stems from the romances that had viewers choosing sides. This is what this post is about. The real romances that have taken place over the last 15 seasons.

Here is every Grey's Anatomy Romance, Ranked.

Izzie Stevens & George O’Malley

George laughing and hiding his face into Izzie's shoulder

Guess the writers wanted to have a little fun with the storylines here. No way this was going to last. George was the quiet guy while Izzie was the outspoken rebel.

Meredith Grey & William Thorpe

We all thought Meredith was ready to get back into the game. However, poor William was the sacrificial lamb letting Meredith know now was not the time to be moving on after Derek's death.

Miranda Bailey & Tucker Jones

bailey and tucker on grey's anatomy

Their marriage was never as important to the show or fans as others. Not too much on-screen time and after a while, we forgot Bailey was even married.

Callie Torres & George O’Malley

George and Callie wearing blue scrubs at the hospital on Grey's Anatomy

The writers have to give George something, right? At that time, Callie was just coming into the picture, sleeping in the basement and aloof from the others.

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Their pairing and marriage were just not of good taste as there was never any real chemistry there.

Derek Shepherd & Addison Montgomery

Addison and Derek in Grey's Anatomy

There was never anything really there for fans to get attached to. By the time Addison came around, Meredith had already stolen Derek's heart.

Callie Torres & Penny Blake

Callie and Penny at a dinner party

Talk about snagging the wrong person. Callie fell in love with the woman who could have saved Derek then turned her against the world and made her move. Penny had a good heart, just bad timing, I guess.

Mark Sloan & Teddy Altman

Mark listening to Teddy Greys

Mark figured it was time to grow up and start a real relationship while Teddy just wanted to have some fun. The sad part is, besides Lexie, they would've been great together.

Arizona Robbins & Eliza Minnick

Not sure what fans hated more, their relationship or Eliza in general? The sneaking around was funny but every time, I wished they had got caught just because.

Lexie Grey & Jackson Avery

By far one of the weirdest romances on Grey's Anatomy. While it was centered around Lexie and Jackson, there was a third party involved--Mark Sloan.

Arizona Robbins & Carina DeLuca

The chemistry between these two was awesome. While the majority of their romance was built upon sex, it was still fun and exciting watching Arizona take charge of her life while engaging with the carefree Carina.

Maggie Pierce & Andrew DeLuca

Maggie Pierce has drinks with Andrew DeLuca at Joe's Bar

Why not? Before Jackson came along, this romance had a chance to become one of the favorites. They both are quiet, keep to themselves and their chemistry was off the charts. But Maggie, not ready to reveal it to anyone, tried to keep it a secret.

Meredith Grey & Andrew DeLuca

Meredith and DeLuca sitting in an elevator in Grey's Anatomy

Didn't see this one coming and now that it's here, sure didn't see it lasting as long as it has. But DeLuca does remind some fans of a young Derek.

Richard Webber & Catherine Avery

Love never dies. Richard Webber deserved it and while Catherine was not the obvious choice in the beginning. She has managed to let her guard down just enough to love Richard back the same.

April Kepner & Matthew Taylor

Matthew fell in love with the right woman but at the wrong time. Being snatched away at your wedding would normally spell doom forever, but these two found a way to make it back to one another.

Jackson Avery & Maggie Pierce

Jackson with his arm around Maggie in Grey's Anatomy

After fans got over the initial reaction of that whole stepbrother and sister issue, this pair seems to work. Maggie is a bit awkward and Jackson is in your face bold.

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The opposites attract theory works well for them.

Preston Burke & Christina Yang

Two headstrong people who put work first, never giving a second thought that their relationship was bound to end tragically.

Jackson Avery & Stephanie Edwards

Was really on the fence regarding this relationship. There weren't too many issues, just weird chemistry. It was as if they were thrown together with no direction.

Richard Webber & Ellis Grey

Let's be truthful here, their affair and love is the real backstory behind Grey's Anatomy. The love was real between the two. So much so that they had a secret child together and helped forge the father/daughter bond between Meredith and Richard.

Meredith Grey & Nathan Riggs

The first real shot at love Meredith had since Derek's death. At first, Meredith put Nathan through the wringer but he never let up. She eventually came around only to lose him to his first love. So hard to watch.

Richard Webber & Adele Webber

Adele and Richard sitting in chairs on Grey's Anatomy

Name a couple that has been through more hardships than Richard and Adele? From affairs to sickness, and death, they stared the storm in the face and tried their best to fight it off.