When a show has too much to offer, it's hard to notice what has been abandoned. Such is the case with the long-running medical drama Grey's Anatomy. Plenty of storylines have been introduced in the show's 17 seasons. Given the bulk, it's understandable that some of the subplots were left hanging.
Perhaps the showrunners forgot about them. Maybe the storylines were deemed not convincing enough to pursue further. Whatever was the case, the show's staunchest fans would have loved to know what occurred. Sadly, that might never happen.
Alex's Massive Debt
For a brief moment, it looked like Alex and Izzie's relationship was going to work. Sadly, Grey's Anatomy's ghost of breakups attacked them too. When fled fled their hearts, Izzie decided to send Alex divorce papers.
Apart from the divorce, Alex had bigger problems to worry about. He was so much in debt and had no idea how to pay. The debt was brought about by Izzie's medical bills while she was being treated for cancer. Alex got into depression and briefly isolated himself from his friends. Interestingly, the debt issue was never brought up again. Alex appeared fine a few episodes later and moved on with life.
Sloan Riley Disappeared After She Gave Birth
Mark's daughter Sloan Riley came looking for him after her mother kicked her out of the house. She hid her pregnancy from Mark and Lexie at first but she was soon forced to tell them.
She had minor complications during her pregnancy but luckily for her, she was under the watch of capable individuals. Riley also opted not to keep the baby, so she and her father discussed adoption as option. After that, Riley disappeared. It's unclear what happened to her or her baby. Even when Mark died, she didn't show up to mourn him.
George And Izzie's Romance
George and Izzie had one of the shortest relationships in the medical drama series. In Season 3, the two were paired up after George cheated on Callie. He had also failed as an intern and Izzie was a shoulder to lean on.
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Geroge divorced Callie to be with Izzie. However, in the following episodes, the relationship was ignored. The two were rarely seen together. What had happened? No one knows for sure. Izzie and George were portrayed as friends in the future. How they moved from lovers to casual friends is a mystery.
Everything Revolving Around Sadie
Some would argue that Sadie is a character that should never have been introduced. She first appeared in Season 5 only for her to disappear after a few episodes. None of the storylines she was accorded led anywhere.
At first, she became too close to Meredith, something Cristina appeared to be jealous about. This storyline was dropped to focus on a new storyline involving Sadie and Lexie's friendship. That storyline was dropped too for one where Sadie flirted with Callie. Nothing came out of that either and Sadie eventually quit her job.
Erica And Callie's Relationship
During a night out, Erica and Callie bonded and developed feelings for each other. They got drunk, played darts, and discussed how they were both not popular among their colleagues. After that, they went out together a couple of times.
While the two were in an elevator, Erica kissed Callie. Things got complicated for them when Erica discovered that Izzie took a heart from one of her patients in order to give it to her patient-lover Denny. She was hell-bent on reporting Izzie, but Callie didn't want to. Angry, Erica quit. An accomplished cardiothoracic surgeon giving up her career for good over a minor disagreement seemed odd.
Izzie's Decision To Leave
After Izzie's cancer scan came out clean, she made the decision to leave Seattle. Meredith begged her to stay because by leaving, she would be abandoned all the people that cared about her. Surprisingly, Izzie argued that Seattle was just where she worked. She didn't consider anyone there as family.
Izzie then left and for a long time, it was never clear what happened to her. Her story was recently revised again in Season 16's "Leave A Light On." Alex called her to check on her. It had been four years since she left. There was another unexpected turn as the two agreed to raise their children together. After all that time? She never addressed her controversial departure either.
April's Religious Beliefs
For a long time, April was a conservative Christian who was abstaining from sex until marriage. She constantly prayed and avoid engaging in any form of acts her faith deemed sinful.
All of a sudden, April went full secular. She allowed Jackson to break her virginity before going on a one-night-stand spree. Why the change of heart? April stopped being a pure soul and decided to be like everyone else. There was no major event that influenced this particular decision. The show just dropped her holier-than-thou storyline.
Callie And Penelope's Second Breakup
Penny's Preminger Grant win came with a condition that she had to be in New York for a year. Callie made the unselfish decision of going with her even though she didn't ask her to. However, when Callie lost custody of Sofia, her relationship with Penny deteriorated, leading to a breakup.
When Arizona decided to bring Sofia to New York to be with Callie for a while, she got back together with Penny. However, in Season 14's "All Of Me,: Callie and Arizona revealed they were both single and looking forward to making each other happy. It's thus not clear why Callie and Penny broke up again.
Sydney's Career Status
Sydney was a surgical resident at Seattle Grace Hospital who Derek became attracted to. They went on a date but Sydney bluntly told Derek that she couldn't commit to him because she wasn't the kind of man she wanted. The two agreed to not let their unfilled romance interfere with their work.
Sydney's words were a relief to Derek because he wasn't sure about her either. Meredith had begged him to not date other women, even though they weren't together and it was good for Derek to honor her wishes. Interestingly, Sydney was never seen again after her date with Derek. Did she finally become a surgeon? Did she date other people?
Derek's Accident
Derek Shepherd's emotional death scene is still fresh on the minds of fans. No other event was as heartbreaking as that particular one. The show mostly focused on storylines involving who was to blame but left out other important parts.
It was revealed that right before the accident, Derek took a shorter route through a valley that had no cell phone signal. Despite this, his phone still rang. He also couldn't hear or see the giant semi-truck approaching as he spoke on the phone. His ID wasn't found either. So many questions were brought up regarding his death but no answers were given.