The series, which will be based on author George RR Martin's Targaryen history book Fire And Blood, already has a plethora of source material for the small screen. Here are five potential storylines for the show to explore...
The Birth Of King's Landing
The penultimate episode of Game Of Thrones, which was divisive with fans, saw fan-favorite Daenerys Targaryen destroy King's Landing. In a symbolic circle of events, it was also a Targaryen who built the city, as it was founded by Aegon the Conqueror and his sisters Rhaenys and Visenya upon their arrival from Dragonstone.
It will be bitter to see the gradual birth of the city knowing its doomed fate, but the construction of King's Landing and, later, the Red Keep will be a big moment in terms of symbolism.
Field Of Fire
There are many great moments from Targaryen history to look forward to seeing on screen, but Aegon's Conquest will arguably be its biggest highlight. The famous Field of Fire, which saw all three Targaryen monarchs take to the skies on their dragons together, was a fiery battle that wiped out House Gardener and forced House Lannister to bend the knee.
Fans have seen dragons in action before on Game Of Thrones, but this should be something else entirely. Aegon's dragon Balerion was said to be big enough to swallow a mammoth whole and all three dragons will be in tandem together.
Elissa Farman
The ill-fated romance between Rhaena Targaryen and Elissa Farman is a bittersweet plot point in Fire And Blood. It signifies another haunting chapter in history for Targaryen queens but also answers another possible mystery from the first season of Game Of Thrones.
Elissa Farman spirited away three dragon eggs from Dragonstone and was rumored to have sold them to the Sealord of Braavos before embarking on an Arya Stark voyage west of Westeros. These dragon eggs are speculated to be the same eggs that Daenerys hatches in the season one finale, birthing her three dragons Drogon, Rhaegal, and Viserion.
Dance Of Dragons
Perhaps the most famous period in Targaryen history is the Dance of Dragons, a fiery and bloody civil war between the Targaryens that almost wiped out their entire house. Aegon II fought his half-sister Rhaenyra after taking the crown promised to her by their father Viserys I. What followed was a war that destroyed nearly all of Westeros.
The Targaryens separated into factions known as the Greens and the Blacks. Nearly all of the Targaryen dragons were killed, and the war was brought to a bloody end after both monarchs died and the crowd passed to Rhaenyra's son, Aegon III.
House Velaryon
The Targaryens were not the only family to flee Valyria before the Doom. House Velaryon ruled from Driftmark, another family of Valyrian heritage. Though they did not originally ride dragons, House Velaryon and House Targaryen married so many times that some Velaryons became dragonriders in their own right.
The Velaryons were House Targaryen's most loyal allies and were prominent figures during the Dance of Dragons.
King Jaehaerys I & Queen Alysanne
Many Game Of Thrones fans were hoping that the romance between Jon Snow and Daenerys Targaryen would parallel that of their ancestors, Jaehaerys the Conciliator and Good Queen Alysanne. The most beloved monarchs to rule Westeros, their love defied the Faith and brought the Seven Kingdoms together, if only for a time.
Both Dragonriders, Jaehaerys was famed as a king who cared about his people and constructed the King's Road stretching from King's Landing to the Wall. Alysanne was loved by the North after her journey to the Wall, where she claimed more lands for the Night's Watch as well as held courts with highborn and lowborn women.
The Death Of The Dragons
House Targaryen may have used the fiery might of dragons to conquer Westeros, but the dragons were only around for half of their rule. After the Dance of Dragons, the Targaryens' biggest weapon slowly began to fade away.
The last dragon to hatch during the rule of Aegon III was no bigger than a cat and died promptly. House Targaryen lost their biggest advantage until Daenerys' emergence from the pyre 150 years later.
Visenya Targaryen
The women of House Targaryen have proved capable and fierce Dragonriders in their own right. Visenya Targaryen not only rode the dragon Vhagar but was also a skilled warrior who wielded the Valyrian steel sword Dark Sister.
Arya Stark mentions Queen Visenya, who was also rumored to have dabbled in dark sorcery, during her season three scenes with Tywin Lannister. It speaks to her legacy that is she is remembered so vividly three hundred years after her death.
Maegor's Reign Of Terror
A true Targaryen tyrant, Maegor the Cruel was the first monarch to display the bloodthirsty viciousness that his ancestors such as The Mad King would replicate. Rumored to have been conceived by sorcery, the son of Aegon I and Visenya had the Red Keep constructed - then murdered all of the workers to contain its secrets.
Maegor's reign is an example of the famed Targaryen madness which so many Dragonriders have succumbed to.
House Stark Supports The Dragon Queen
The alliance between House Targaryen and House Stark in the final season of Game Of Thrones was fragile. Despite aiding the North during the Long Night against the Army of the Dead, Sansa Stark remained distrustful of Daenerys, having a hand in her downfall after revealing the secret of Jon Snow's parentage to Tyrion Lannister.
In a stark juxtaposition to this, the Northern forces supported Rhaenyra during the Dance, riding south to avenge her death. Cregan Stark served as Hand of the King to Rhaenyra's son, Aegon III.