Disney+'s The Falcon And The Winter Soldier has continued to tackle the issues that arise from the Super Soldier Program, which originally gave Steve Rogers his powers back in the '40s. Alongside the arrival of the villain known as the Power Broker, a range of other characters have been introduced that have some kind of connection to the Super Soldier Serum originally created by Doctor Abraham Erskine.

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The comics have a whole range of characters impacted by this serum. While the MCU has seen a variety of them adapted to screen, it has also introduced its own variations of these characters, such as Patriot in Marvel's Agents Of S.H.I.E.L.D. By looking at this wide roster of characters, it could say something about the future of the Disney+ show and the Marvel Cinematic Universe in general.

MVP/KIA

MVP/KIA Avengers The Initiative Comic

One of the things that Captain America: Civil War overlooked was the aftermath of the conflict, which played out in the comics. With Tony Stark as the new head of S.H.I.E.L.D. and a leading member of the world's security services, he comes up with a number of ways to make the world better.

One such way, accompanied by Hank Pym and Reed Richards, was to create a superhero team in every state: The 50 State Initiative. Michael Van Patrick or MVP was brought into the initiative and was the great great grandson of Erskine. Although never given the serum, he was a perfect super soldier thanks to a strict exercise and diet regime. His death and cloning would eventually create the superpowered villain KIA.

Bucky Barnes

Bucky and Black Widow stand back to back with guns in their hands

Of course, it's no secret that in the Marvel Cinematic Universe Bucky Barnes is one of the few super soldiers left. As the sidekick Bucky, he fought alongside Captain America, before he would get captured by Hydra and experimented on. On-screen he has been both The Winter Soldier and The White Wolf.

In the comics he also took up the mantle of Cap himself, wielding the shield for quite some time. It wasn't Hydra that came to brainwash him and give him their version of the Super Soldier Serum but instead the Soviets who created The Winter Soldier. There have been a number of alternate iterations of the character in the comics, each more dangerous than the last.

Isaiah Bradley 

Isaiah Bradley Captain America

Isaiah Bradley is another character that The Falcon And The Winter Soldier has brought to screen for the first time, but has a storied history in the comics. As part of a dangerous Super Soldier program, the military experimented on African American candidates to create the perfect weapon.

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Isiah Bradley took up the mantle of Captain America after being the sole survivor of the project but would eventually be arrested for his service. His legacy is continuing to be honored thanks to his grandson, who will be brought back up later, but Bradley is perhaps one of the most heroic men to ever take the Serum.

Steve Rogers

Captain America punches hitler

Is there really any other super soldier as crucial as Steve Rogers to Marvel Comics? The most well-known iteration of Captain America has an incredibly similar origin story in the comics as he does on screen. While not an original Avenger, he is their most well-respected leader.

He has taken on the burden of being a super soldier for many years, struggling with his identity many times over. From Cap to Nomad and an unfortunate period of time as a shifted Hydra Supreme, Rogers has really held every role in the Marvel Universe including as both the leader of S.H.I.E.L.D. and as an underground hero.

Elijah Bradley

Eli Bradley charges as Patriot

The Bradley family line is a strong one as Eli's grandfather was Isaiah, a previous Captain America. Eli wanted to continue on the same path and would eventually suit up as Patriot as part of the Young Avengers. Unfortunately, at the start of his career, he lied about his abilities.

It was eventually revealed he had no powers at all, but he would later live up to his claim, becoming a super soldier in his own right. He has a long history with the Young Avengers group as their leader and looks to be introduced in the MCU, perhaps as a larger initiative to bring the team to screen for the first time.

John Walker

USAgent John-Walker in the comics with a shield

John Walker is known as U.S.Agent in the comics, but for fans of the Disney+ show, he is currently the government-approved Captain America. In both iterations, he's pretty loose on what justice is, gets his abilities from the Power Broker, and isn't afraid to wield a firearm when needed.

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Both versions also demonstrate what can really happen if it isn't a good man that takes the Super Soldier Serum. Walker has tried to be a hero, but he is usually portrayed more like the Punisher; an anti-hero that ultimately gets the job done, but at what cost?

Robert Reynolds

Sentry's in full costume surrounded by smoke and lightening

Robert Reynolds was a part of the Golden Sentry Serum project, which took place in the late '40s and was an attempt to replicate what had been achieved with Steve Rogers. The final result was not anything that could have been expected, with the program getting shut down.

The Sentry was born thanks to this, an incredibly overpowered hero with a dark secret. Sentry's nemesis was a villain known as The Void. Yet, this turned out to be another aspect of Sentry's own personality. Reynolds would go mad, culminating in a violent outburst in Marvel's Siege storyline, which included Sentry's murder of the Greek god of war, Ares.

Natasha Romanoff

Black Widow in Marvel Comics

Natasha Romanoff is the most well-known version of Black Widow, although the MCU version of the spy was trained under the Soviets in the Red Room. This is also the case in the comics, with the addition of an experimental Super Soldier Serum.

While not making her quite as powerful as some of the other heroes who have taken a Serum, Black Widow has demonstrated that she is at the peak of human physical endurance, as well as showcasing great athleticism and speed. Black Widow has thus become a vital member of the Avengers and one of its longest-serving members.

Carl Lucas

Luke Cage And Iron Fist 2016 Marvel Comics

Carl Lucas was the subject of a number of experiments by the Nazi Doctor Noah Burstein. His own version of the Super Soldier Serum created Power Man, a hero with invulnerable skin and enhanced strength and durability. These powers would put Lucas on a new path.

Of course, Power Man is more well known as Luke Cage today, a name that the hero took on as he continued to shift what he really stood for. A Hero For Hire, an Avenger, and a Defender, the character has been introduced through the Netflix shows on the latter team although could make a re-appearance down the line.

Todd Ziller

American Kaiju, Corporal Todd Ziller

Every now and then the American military revisits their Super Soldier Program and tries to create a new hero that can represent the country. Todd Ziller was one of the latest candidates to undergo the process, but the gaps in the science were replaced with Gamma technology.

The results of the Serum and the radiation created a creature known as American Kaiju. A Godzilla-like beast, Ziller ended up less super soldier and more terrifying monster. With the addition of the Pym Particles and Doctor Conner's work, this beast was almost unstoppable.

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