David Tennant's Tenth Doctor and Catherine Tate's Donna Noble have amazing comedic chemistry. Their Doctor-Companion relationship was a fresh and exciting dynamic on Doctor Who. The pairing balanced their intense, serious, and tear-jerking moments with their humorous banter and hilarious facial expressions.

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Donna was The Doctor's best friend. They laughed together, felt "all-right" together, told each other what they needed to hear, and embraced a sense of adventure. Just two mates hopping around time and space. With a comedic duo this perfect, there are some scenes that are too funny for audience members to forget.

Their First Meeting

When Donna's Huon particles zapped her into the TARDIS, so began one of the best platonic Doctor-Companion relationships of the revived season. Audience members knew that when The Tenth Doctor starting saying the three whats in varying inflections, things were about to get interesting. Donna perplexed The Doctor. Comedy ensued as she called him a martian, yelled at him about wedding dress pockets, and winked at him when she got everyone's sympathy at the reception. The two laughed at the hilarity of riding scooters, and The Doctor was bemused when she slapped him. And who can forget when he failed to catch her as she swung Tarzan style from the Racnoss web?

Ten II & Donna's Interaction

Series 4 foretold the ultimate ending, the "Doctor Donna." Donna was caught in an instantaneous two-way biological meta crisis when she touched The Doctor's severed hand, pumped full of regenerative energy.

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The result was a human Doctor, a Doctor mixed with the DNA of Donna Noble. Metacrisis Doctor, "I grew out of you, still...could be worse." Donna, "Oi, watch it, Spaceman!" Metacrisis Doctor, "Oi. watch it, Earthgirl! Oh...I sound like you."

When They Made Dark Situations Humorous

Season 4 had some dark episodes, but whenever The Doctor and Donna were together, things didn't seem so bad. In "Silence In The Library" and "Forest Of The Dead," Donna yelled at The Doctor about The Sonic Screwdriver's inability to work on wood during a high stakes moment and kicked open the doors to safety.

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They tore forms they had to sign and Donna kept The Doctor's ego at bay when he was called "pretty boy." During the companion-lite episode "Midnight," they made a dinner date which wasn't really a date and had some banter before The Doctor's perilous trip on a space truck with a bunch of strangers.

The Sontaran Spaceship

Donna's stuck in the TARDIS which would be okay if she wasn't on board the Sontaran stratagem ship. But who better to instruct a walkthrough earth-saving mission than The Doctor on the phone? Donna knocks a Sontaran unconscious "back of the neck," with The Doctor encouraging her and reminding her "you've got three fingers." It's a high stakes situations and the tension is high, but these two communicate in the language of banter. "You are brilliant you are." Donna's response? "Shut up." In an episode riddled with funny moments, Donna also managed to make fun and call The Doctor a dumbo when he thought she was leaving for good but was only really visiting home. "Big outer-space dunce."

The Water Pistol Escape

"You fought her off with a water pistol. I bloody love you." In "The Fires Of Pompeii," Donna gets abducted by the Sibylline Sisterhood to be used as a sacrifice. But The Doctor would never let anything happen to his best friend, so armed with a water pistol and a babbling head full of questions, he goes in to rescue her.

The Mime Performance (Reunion)

Donna had been looking for The Doctor every day since she turned down his offer to travel with him. "Partners In Crime," followed their separate investigations into Adipose Industries and ridiculous near-miss interactions until they were finally reunited in a scene of comedy gold. Donna, watching from the door window as Miss Foster revealed the true reason for the fat just walking away, looks across her just as The Doctor, who is watching from the window cleaning cradle, also turns. The scene that follows comprises of Donna miming her journey to find The Doctor and his invested reactions to her dedicated storytelling.

When They Became Detectives

"The Unicorn And The Wasp," provided hilarious Doctor Donna content as the two attended a fancy 1920s party. But mingling and drinks quickly became "murder, a mystery, and Agatha Christie," as party guests were killed off one after the other. The Doctor and Donna assumed investigative aliases and so began one of the best examples of their comedic chemistry. Donna's constant comments during the dramatic moment of revelation replicated the voice of the episode viewers as they too watched the unfolding of the investigation.

The Cyanide Cure

Although "The Unicorn And The Wasp," was an example in itself, specific mention must be given to The Doctor's poisoning detox. Once the murderer realized the investigation was dangerously close to being solved, they tried to kill the catalyst, The Doctor.

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After drinking the sparkling cyanide, The Doctor went down to the kitchen with Donna and Agatha in his wake, and in a dance of agony, mimed the ingredients for his cure. All that can be said for these two is that they would make a terrible, yet very entertaining charades team.

Mistaken For A Married Couple

A running joke during the adventures of The Doctor and Donna is that they are constantly mistaken for a married couple. This occurs in "The Fires Of Pompeii," "Planet Of The Ood," "The Doctor's Daughter," and "The Unicorn And The Wasp." Their response? "Oh no no no, we're not married," "we're so not married," "never ever," "I'm not his woman," and "we're not a couple." On one refreshing instance, after they are mistaken as married, they are referred to as brother and sister due to the shared name, Spartacus. Their response? "Really?"

"I Just Want A Mate"

After Donna has finished piling her luggage into the arms of The Doctor, he hit her with a doozy. "I just want to mate." Of course, what he had really said was "I just want a mate." This moment of misunderstanding established that The Doctor and Donna were going to be on the same wavelength and that there would be no romantic surprises or nonsense during their time together. At the risk of sounding cheesy, it looked to be the beginnings of a great friendship.

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