One of the most interesting dynamics in Marvel comics is between the friendly neighborhood Spider-Man and the anti-hero Deadpool. The two had butted-heads and teamed up several times in Marvel comics, and the prospect of seeing this relationship translate to the big screen is extremely promising.
Many fans expect Spider-Man to
usher in the next phase of the Marvel Cinematic Universe after the events Infinity War, and introducing one of the newest fan-favorites in Deadpool would be a great way to kick things off.
Based on their characters, it's unlikely that the duo will get along in the beginning. They may be positioned as adversaries, but eventually work together to face a more substantial threat. It would be a more comical version of what we see when The Punisher and Daredevil meet in the Netflix series.