It's no secret that Deadpool is one of the weirdest and most insane characters in the Marvel Universe. However, that doesn't mean that he can't have a heart and do some good when he feels like it. And if that's the case, why doesn't Wade Wilson donate his blood and/or organs to those in need? Thanks to his impressive healing factor that's on par with that of Wolverines', couldn't he just heal and grow those body parts back? Unfortunately, there's some pretty strong evidence as to why that would be a bad idea and wouldn't work out so well, like in the 2014 miniseries, Night of the Living Deadpool.
Night of the Living Deadpool was written by Cullen Bunn with fantastic black, white, and red art by Roman Rosanas. In the story, Deadpool wakes up from a coma to find that the Zombie Apocalypse has begun - much like The Walking Dead's Rick Grimes, though Deadpool's coma was just from eating too many chimichangas. As he walks around, he finds that the majority of the world has changed and a zombie virus has swept the globe. Unfortunately for Wade, he can't even enjoy killing the zombies, as they seem to have retained some of their memories, crying for help instead of just moaning and groaning, which really kills the buzz for Deadpool who was hoping it would be more like in video games. Unlike other Marvel Zombies stories, Deadpool looks like he's the only superhero left, though he thankfully doesn't have to deal with super-powered zombies in this story.
After a while, Deadpool does find survivors, eventually seeking refuge with a small town that has been barricaded in Night of the Living Deadpool #3. Inside, he meets Clarence, a former AIM scientist who reveals how the zombie virus began. According to Clarence, he was part of a subgroup known as AIR (Advanced Ideas in Regeneration). In their project, they were trying to unlock the key to overcoming death, and part of their experiments involved working with healing factors, using tissue and blood samples they had secretly collected over the years.
Thanks to Night of the Living Deadpool, fans now know why it's a bad idea for Deadpool to donate blood. It seems as though there's some pretty nasty side effects, like kickstarting an entire zombie apocalypse and the end of the world. When Wade breaks into an AIM lab to try and find a way to make things right, he even finds cloned bodies of himself that AIM had created from the samples they took from him, confirming that his genes and DNA were instrumental in the creation of the virus.
The reason for this could be that Deadpool's healing factor actually heals over the cancerous and mutated cells that cover his body, explaining why he hasn't died from them as well as why his skin and body look the way they do. Using common sense, that right there seems like it would take DP out of the running to be an ideal donor, but apparently AIM overlooked this element. Long story short, Deadpool should never be a donor. Ever.