It's only fitting that an original character who was created for an animated series get one for herself. Harley Quinn first appeared in Batman: The Animated Series in 1992, which took the characters and thematic elements of Tim Burton's 1989 film Batman and carried them over into episodic adventures for the Caped Crusader. Now almost 30 years after she arrived in Batman canon, she gets her own chronicle in DC's Harley Quinn.
The animated series showcases a newly single Harley, who's ditched the Joker to make her own mark on Gotham City as a notorious queenpin. Just like in Batman: The Animated Series, the cast is full of recognizable voices from actors who bring life to the many characters in the Batman franchise.
Kaley Cuoco - The Big Bang Theory
The Clown Princess of Crime is played by one of the most recognizable faces working in television today, Kaley Cuomo, who thanks to her role as Penny in The Big Bang Theory has become a beloved comedic talent.
Like Harley Quinn, Penny was underestimated by those around her, especially since she was considered to be of "average" intelligence compared to her group of friends on the show, genius-level engineers and theoretical physics professors who also happened to love comic books. Her character was the most relatable, and represented the audience's point of view as she navigated life among a bunch of lovable nerds.
Lake Bell - In A World
Lake Bell, who plays Harley Quinn's friend (and maybe more) Poison Ivy became a triple threat when she directed In A World, a comedic spoof about the melodramatic world of voice acting.
Bell portrayed a version of herself, a voice actress who competes against her father and his biggest rival to land a high-paying voice-acting gig doing the narration of a blockbuster movie trailer. Witty, self-referential, and poignant, her character -like the film- is indicative of her major talent. Recently, she can be seen in other comedic series like Bless This Mess and BoJack Horseman.
Alan Tudyk - Firefly
The versatile Alan Tudyk has been lending his chameleon-like vocal abilities to many series, but for many fans he'll forever be Hoban "Wash" Washburne from Joss Whedon's Firefly. The show combined the best elements of the science fiction and western genres and garnered a large fandom.
Other than portraying Calendar Man on Harley Quinn, Tudyk has played K2SO in Rogue One: A Star Wars Story, King Candy in Wreck-It Ralph, and the AI being Sonny in I, Robot.
Christopher Meloni - Law & Order: SVU
Christopher Meloni lends his tough-talking talents to the voice of James Gordon, and the role of Gotham City's Police Commissioner couldn't be more appropriate given Meloni's penchant for playing law enforcement in shows like Happy! and Law & Order: Special Victim's Unit.
For twelve seasons on SVU (now the longest running drama on network television) he played Detective Elliot Stabler, a hard-boiled New York City detective who sometimes let his emotions get the best of him. He'll return as Elliot Stabler in his own series coming soon to NBC, Law & Order: Organized Crime.
Diedrich Bader - The Drew Carey Show
Though he's primarily known for his goofy characters in television and films, Diedrich Bader has been providing the voice of Batman for years in Batman: The Brave And The Bold, and most recently as a foil for Harley Quinn in her titular series.
In the '90s. Bader starred alongside Drew Carey in The Drew Carey Show as Carey's dopey friend Oswald. More recently, fans can see him in American Housewife and the NBC ensemble comedy Outsourced.
Wanda Sykes - Black-ish
Named one of the Top 25 Funniest People in America, Wanda Sykes has made a name for herself in the film and television industry for over three decades. She appears in Harley Quinn as the mysterious Queen of Fables.
She began writing for The Chris Rock Show and was instantly recognized for her talent, and has recently appeared in Black-ish in a reoccurring role as Dre's boss. Prior to joining the cast of Black-ish, she could be seen in several popular series like The New Adventures Of The Old Christine and Curb Your Enthusiasm.
Jason Alexander - Seinfeld
Jason Alexander plays Sy Borgman on Harley Quinn, her unassuming landlord who used to be a government agent. For millions of fans, Alexander will always be perpetually grumpy George Costanza, Jerry Seinfeld's cynical friend on Seinfeld.
Seinfeld ran for 9 seasons and was known as one of the most iconic shows of the '90s, if not one of the most popular series of all time. Alexander received nominations for seven consecutive Emmy Awards for his comedic genius as George.
Alfred Molina - Spider Man 2
With a long career on the British stage, it shows the range of versatile character actor Alfred Molina that he should be so well-known for playing Doctor Octopus in Spider-Man 2. On Harley Quinn, he portrays another notable supervillain, Mr. Freeze.
Eagle-eyed fans of the Indiana Jones series may note his brief appearance as Indy's guide who tries to steal the idol in Raiders of the Lost Ark, Molina's first film role in the United States. He's appeared in several dramas as well including Frida and Chocolat.
Tom Hollander - Pirates of the Caribbean 2 & 3
Tom Hollander appears in the series as Alfred Pennyworth, Batman's trusted friend and butler. Hollander has lent his vocal talents many times over the years to characters on The Simpsons, Family Guy, and Bob's Burgers. As Alfred, he brings class, distinction, and crime-fighting finesse to the part.
Fans may recognize him as Lord Cutler Beckett, one of the main villains in the Pirates of the Caribbean film series. Recently, he was seen alongside Tom Hardy in the moody BBC historical epic Taboo.
Michael Ironside - Starship Troopers
Known for playing heavies in action films in the '80s and '90s, Michael Ironside lends his malevolent vocals to Darkseid in Harley Quinn, taking on one of the most fearsome comic book villains since Thanos.
One of Ironside's most memorable turns was as Jean Rasczak in Starship Troopers, which continued his tradition of appearing in science fiction films like Total Recall and Turbo Kid.