The DC Universe is vast, it contains multitudes; heroes, villains, sidekicks, and vampires. The DCU is not a hotbed of vampirism, but it has underground armies led by powerful and evil vampires and vampires that are dedicated to stopping them. The first vampire in the DCU was in 1936, fighting Doctor Occult a creation of Jerry Siegel, and artist Joe Shuster who would also create Superman. Occult won. Batman would also fight a vampire in 1939, dispatching the nest with an automatic full of silver bullets.
The modern age DC vampire can be much more explicit - and bloody - than in the Silver or Bronze Ages, and there are more than ever before in the New/Old/Prime Earths. They range in power and strength, in age and organization, in good and in evil. Some are ageless and gather more power for the battle against humankind, others gather forces against those who would feed on humans. All are DC's most powerful vampires.
Vincent Velcoro
After wounding a superior officer, Vincent Velcoro is given 30 years and thrown into the brig. He's offered his freedom if he joins the newly formed 'Creature Commandos' run by Project M. The scientist injects him with a serum that gives Velcoco the powers of a vampire and sends him and the other Creatures off to fight the Nazis.
The other Commandos were; Pvt. Elliot "Lucky" Taylor (Frankenstein), and Pvt. Warren Griffith (werewolf), under the command of Lt. Matthew Shrieve. Velcoro has many vampire powers, but cannot transform others into vampires as he is not a 'true' vampire. He can, though, be seen in mirrors.
Natalia Mitternacht, Nocturna
Nocturna, thief, hypnotist, vampire. Immortal and sensitive to light, she uses her powers to steal and her hypnotism to control people and force them to her will, even force them into 'romantic' relationships. She forces Kate Kane, Batwoman, into a relationship after discovering her identity and getting close enough to bite her. Through her bite, she makes Kate break up with her girlfriend and start a relationship with her. Kate's sister figures out what is going on and snaps her out of it. Nocturna is a strong vampire, but she is a strong and more skilled thief and powerful hypnotist.
Mary, Queen Of Blood
Once Mary Seward, fiance of Lord Andrew Bennett, now Mary, Queen of Blood and leader of the Blood Red Moon cult and sworn enemy of Andrew Bennett, Lord of the Vampires. Turned on her own request by her lover Andrew, Mary was too weak to stick to Andrew's vow of not killing humans and gave in to the lust for blood and power.
While Andrew Bennett sees the value of human life, she sees that as his weakness. To her, humans are to be consumed and used for her army or thrown away. She has the powers of most vampires; super strength, transformation into a bat, or mist, or wolf. In a twist, sunlight can weaken her, but won't destroy her.
Starbreaker
Starbreaker, also known as Luciphage or “light-eater" on the planet Thanagar, is an energy vampire and adult sun eater known for draining planets and suns of their energy. Starbreaker also has discovered that the best time to drain humanoids is when they're terrified or close to death, so he's learned how to make both come about.
Starbreaker battled the Justice League in the '70s to a near standstill a few times first when trying to invade Adam Strange's adopted plane Rann with giant, mechanic ants, and then helped instigate the Rann-Thanagar war. But so far, he's always managed to lose despite being an immensely powerful energy being.
Cain
Cain, cursed by God, is the father of all vampires, the original from which sprang the cursed breed. He walked across Saxony and Albion, creating an army of vampires to subjugate humankind. To fight him, Al-Jabar the mathematician and scientist who was roaming Europe, located Horsewoman, Exoristos, and Sir Justin, forming the Demon Knights to stop Cain. They succeeded, saving humankind from the rule of vampires, for now.
Cain was the vampire who turned Andrew Bennett, mistaking his passion for Mary as lust. Because he was innocent, Bennett was able to control his bloodlust. Cain, as the father of all vampires, has all the powers they process but stronger as he is the original, the source. Cain is also a capable wizard, able to siphon off the power of other magic users to add to his own.
Looker
Emily 'Lia' Briss. She was originally a hero teamed with Batman and the Outsiders, fighting crimes and various menaces. She was turned into a vampire when trying to rid Markovia of a vampire infestation when she was bitten by their leader, Roderick. She became a 'daywalker' and Roderick's mistress, fighting her former teammates when she was brought out of the leader thrall by being reminded of her husband.
In addition to her usual vampire powers, Looker also telepathy, telekinesis, she can fly and project energy. She uses these powers to aid groups like Batman the Outsiders.
Andrew Bennett/I, Vampire
Andrew Bennett was a Lord in the court of Queen Elizabeth, a rising courtier known for his good looks and strong will. Bennett was attacked by the original vampire Cain and left for dead, but rose three days later, fully undead. Knowing now the horror of his existence, he vowed never to take the life of another human. He broke this vow for his fiance, Mary Seward. Mary, seduced by the power of vampirism, left Bennet and started a cult, the Blood Red Moon. They would pursue each other for centuries, Andrew working to thwart Mary's plans.
Andrew is an experienced vampire, knows his powers, their limits, and his own. He's a former member of Justice League Dark and is known as the 'Lord of the Vampires', as he works to keep the vampire population down so they don't become an overwhelming threat to the living. He is a formidable foe and powerful ally.