Daredevil's Netflix show and recent MCU re-debut thanks to Spider-Man: No Way Home (and Kingpin's in Hawkeye) has helped bolster the Man Without Fear's mainstream popularity. His small corner of the greater Marvel universe is one filled with compelling, intimate stories and characters.
Understandably, the supervillains like Kingpin and Bullseye hold the highest ranks of Daredevil's rogues' gallery, but there are plenty of others that can pose serious threats. The likes of Typhoid Mary and the Owl are surely ones who've been thorns in Matt Murdock's side, and comic book fans are likely hoping these characters get a second chance in the MCU.
Kingpin
Especially after Vincent D'Onofrio's powerful performances and portrayal of the character, fans have become well aware of the force that Kingpin's sheer presence holds. The level of intensity that Daredevil and Kingpin's hyper-violent rivalry reaches is a testament to how big of a threat he is.
However, part of what makes Wilson Fisk such an imposing figure is more so his intelligence and cunning as a top crimelord in New York. Kingpin functions as the city's (and Daredevil's) dark architect that, more often than not, is two steps ahead of his enemy.
Bullseye
In both the comics and the acclaimed TV series, Bullseye is responsible for some of the worst things to ever happen to Daredevil. His nature makes his skills as an assassin that much more dangerous. Since he was a child, Bullseye has never had a sense of morality and that lets him kill for pure catharsis with nothing to emotionally hold him back.
He has incomparable skills as a marksman with just about anything he can get his hands on. A supervillain that could make any everyday object into a lethal weapon is not one to take lightly.
Typhoid Mary
One of the differences between Daredevil in the MCU and the comics was the use of Typhoid Mary as a villain. She is only featured in the poorly-received Iron Fist series but is a notorious and recurring villain to Daredevil in the comics. And, as Matt Murdock's tumultuous life tends to progress, Typhoid Mary was a romantic interest to him at one point.
Her extreme disassociative identity disorder is part of what makes her so dangerous, as she has the more timid "Mary" personality, the violently adventurous "Typhoid" personality, and the brutally sadistic "Bloody Mary" personality. Pairing her personalities with her low-level telekinetic and pyrokinetic powers makes her a real terror.
The Owl
Leland Owlsley featured as the Netflix version of the Owl, though, he was more of a typical corrupt businessman.
He's also much more important in the comics, even if Daredevil finds him to be an insufferable nuisance. But unlike other nuisances like Stilt-Man, Owl is also a cunning mobster in his own right. His enhanced strength, reflexes, and senses also complement his erratic and irritable behavior enough that he is very problematic to deal with.
Ikari
Mark Waid and Chris Samnee's tenure on Daredevil was praised for bringing back some of the more upbeat and adventurous tones of the 1960s, but also balancing it with grounded themes to keep true to the spirit of the character's most celebrated incarnations. The duo introduced a menacing new baddie in the process by way of the mysterious Ikari.
His identity remains unknown but it appears his origins mirrored Matt Murdock's accident and resulting powers. Kingpin contracted the assassin to fight Daredevil to the death. It culminated in a grueling hours-long fight in which the Man Without Fear was nearly beaten to death, with Ikari matching and even surpassing Daredevil's skills.
The Hand
Somewhat similar to the League of Assassins for Batman in DC Comics, The Hand is a mysterious and ancient order of mystical ninjas. The level of power they hold is expected with a group with this premise. Their leadership has fluctuated over their history with the likes of Elektra, Typhoid Mary, and even Daredevil becoming the tip of their spear.
While the League of Assassins at least operated on a bizarre mindset of what they think will achieve justice, The Hand is unabashedly tied to organized crime. The Hand ultimately craves power and domination above everything else, utilizing occult magic and their notoriety within the criminal underworld as tools to achieve their goals.
Elektra
Elektra started as a villain to Daredevil when writer Frank Miller introduced her, before transitioning into an anti-hero and, finally, a superhero. Regardless of her moral role, Elektra has featured in many of Daredevil's best comic book arcs.
In Zdarsky's comics, she's even serving as Daredevil in Matt Murdock's place as well as alongside him. Elektra has always been a complex love interest, but she was also a lethal force when standing against him. Like Matt, she was trained by Stick to be an expert-level ninja specializing in her classic twin sai weapons.
The Stromwyns
The brother/sister team of Quinn and Una Stromwyn are newer to the mythos since their first appearances were in Chip Zdarsky's run on the series. Regardless, they've already made a powerful impression. It's not superpowers or any other kind of physical prowess makes them notable, but their status in the organized crime world does.
They're a pair of uber-rich crimelords whose influence and power measured much higher than even Kingpin. The Stromwyns' strength can't be contained at a state level, as their reach can span the country. Their nonchalantly-callous, yet cheery attitude also adds to their intimidation factor, especially when striking fear into Kingpin himself to his face.
The Purple Man
Zebadiah Killgrave/Purple Man mirrored Kingpin's beginning and progressed in his comic book history. While Kingpin started as a Spider-Man villain, he became a shared villain with Daredevil and even became more synonymous with the latter. The Purple Man had a similar transition, but from Daredevil to Jessica Jones.
He's a street-level supervillain, but the scope of his powers could reach much further if he tried. In addition to regenerative abilities, he possesses a pheromone that allows him to control other people. Purple Man was most notably an antagonist for Daredevil in Waid and Samnee's Daredevil series.
Kirigi
The ninja Kirigi is an important figure in The Hand's history. He was a legendary member of the group who was capable of resurrection. Most importantly, his powers become more enhanced each time he is brought back to life. Given his alignment, Kirigi is also a natural enemy of The Chaste -- the group of warriors organized by Stick to combat them.
The ninja has proven more than a handful for both Daredevil and Elektra, with the latter almost being killed at his hand. It seems like an altered version of the villain was used in seasons 1-2 of Daredevil in the form of Nobu, as it's referenced that he's gone by many names.