We've already met two different big screen versions of Norman Osborn (played by Willem Dafoe and Chris Cooper) - one of the most infamous villains of Marvel Comics, thanks to Sony Pictures' two attempts at establishing a Spider-Man movie universe. Both of them were seemingly killed off quickly but not before leaving fans with several versions of the Green Goblin character.
With the next iteration of Peter Parker a.k.a. Spider-Man (Tom Holland) fitting into the MCU, Sony and Marvel should take an entirely different approach with their version of Osborn. He and his company, Oscorp, are just too important to the Spider-Man mythology - and now the greater Marvel universe - for him not to have a key part to play. And there are already rumors of of Matthew McConaughey reading Marvel movie scripts and potentially being eyed for the Osborn role.
Any new version of Osborn should let him take a more political role, one that makes sense to include in Civil War given its political nature, especially now that Spider-Man is in the mix too. Osborn's Green Goblin stories don't need to be part of the story for a while, but his hatred of Spider-Man can still be a through line in other stories where - like in the comic - Osborn leads the Thunderbolts, a team of reformed supervillains and a comic book property James Gunn (Guardians of the Galaxy) very much has an interest in making.