So, we can eliminate those two from who Campbell could play. Some online speculation on Campbell's possible villainous role point towards Mysterio, an illusionist and special effects expert who wears a... fishbowl for a helmet.
If Mysterio were the main villain or one of two villains of the movie, who could be the other? Could they go ahead and finally evolve the character of Dr. Curt Connors played by Dylan Baker? Or could they save that for when they actually want to do Morbius?
If we did get an appearance by The Lizard, they could still tie that into Spider-man 5 or 6 because we know they wouldn't kill off Dr. Connors and that could allow for Morbius to show up in later movies (assuming they ever go that path and actually have the rights to the character).
There are so many characters to choose from and so many that fans want to see. I'm excited to see Bruce play any of them but I can't say I'm a big fan of Mysterio - I never really dug him as a Spidey villain personally.
With the re-writes for Spider-Man 4 we’ve been hearing about and a new writer hired for Spider-Man 5 & 6 to prepare the next installments as a franchise reboot (if necessary), I hope this film is being made for the right reasons and is done right.
Are you excited to hear that Bruce Campbell will be playing a much bigger role this time around and if it's a villain, who do you think it could be?
Spider-Man 4 begins principal Photography in January 2010 and is scheduled to hit theaters May 6, 2011.
Source: Access Hollywood, 2nd image edited from work by Sony Forums user, Calebyourmaster