Bob's Burgers is a lovable and well-received animated show that has a wide variety of different characters who appear frequently throughout the show. Most of the characters would act differently if put into a horror movie situation where they were on the run from a masked killer.
There are certain characters who would be killed immediately while others would be able to hide or fight well against the threat. Each Bob's Burgers character has their own particular personality and falls into a wide spectrum of whether they would fare well or badly in a horror movie.
Gayle
Linda's sister Gayle would certainly not survive a horror movie given all of her fears, worries, and particulars of her life she needs from her countless cats to her particular sleeping arrangement in place to survive.
Gayle most likely would immediately break if she were in a horror movie situation, not know what to do, start screaming, and direct the killer right where she was attempting to hide.
Mr. Frond
Mr. Frond is very similar to Gayle and there's a reason why the two were shown dating for a while in the series. Mr. Frond is the kids' guidance counselor and like Gayle, he tends to need things in a particular way to be able to function.
In the episode where the bank across from the Belcher's working-class restaurant is being robbed, Frond happens to be a hostage, and he does not fare well in the situation making his surviving a horror movie unlikely.
Gene
Gene might be able to scare the killer for a moment and disrupt his rhythm, but it most likely wouldn't save him in the end. Gene is a loud and particular kid and would likely give away their location accidentally while hiding from the killer.
Gene would add some much needed comic relief to the movie, but typically those characters are killed in horror movies about halfway through.
Jimmy Jr.
Jimmy Jr. is a classmate and constant crush of Tina's who is absolutely obsessed with dancing. Jimmy Jr. could try to keep his obsession and need to dance quiet, but multiple times on the show he's shown that he can't hold it in and would likely stop to angry dance in the situation and get killed over it.
Tina's more likely to last longer than Jimmy Jr. or her other classmates like rich frenemy Tammy would, which is a pretty typical trope in the horror genre.
Zeke
Zeke is Jimmy Jr.'s best friend and would probably fare about as well as his friend, but he does have wrestling and fighting skills that might be able to fend off a killer for a little while.
Typically, Zeke and Jimmy Jr. are always together and would likely stay together hiding out in a horror movie, but would both be caught and not able to successfully fight off the killer.
Teddy
Teddy is a constant customer at Bob's Burgers restaurant and he cares for Bob, Linda, and the kids very deeply. Teddy is shown over and over again on the series that he doesn't perform well under stress and would most likely break if he was in a horror movie.
Teddy's personality mixed with the fact that he would sacrifice himself for the Belchers without a second though means he likely wouldn't survive a horror movie.
Linda
Although Linda is somewhat similar to her sister Gayle and her son Gene, she would most likely last longer in a horror movie. She has a bit more smarts and is quick to adapt to her given situation and she can be a fierce fighter especially when she's protecting her babies.
Linda would likely be able to fight off the killer while her family escaped, but probably wouldn't be able to last until the end of the movie.
Tina
Tina is a pretty quiet kid and would most likely be the best at hiding from a killer of all the Belcher children. She'd most likely be able to hide out until the end when the killer was apprehended and might not even have to fight him at all.
It takes a lot to get Tina worked up and she might not catch onto things happening in the horror movie as quickly as other characters, but she still has a pretty good chance of surviving until the end.
Bob
Bob is a pretty quiet character until he gets worked up around his family or the restaurant, but that typically takes a lot and he's one of the last Belchers to break in any given situation. Because of his laid-back nature, Bob would probably fare well in a horror movie.
Most likely Bob would keep a level head, for most of the time at least, and be a good protector of his family without necessarily having to sacrifice himself for them all, meaning that he's pretty likely to survive until the end of the movie.
Louise
Louise is known for her devious and conniving schemes and would most likely be able to survive until the end of a horror movie and certainly has the best chance of all the Bob's Burgers characters to survive a killer.
Although most of Louise's adventures are in her fantasies, Louise has still proven that she's great at coming up with and planning schemes, which usually get her in trouble, and might not always work out exactly the way they're supposed to but would certainly help her make it to the end of a horror movie and defeat the masked killer.