As we get ready to see the final chapter in the new X-Men trilogy with the release of X-Men: Apocalypse later this year, we thought we’d take a look at the most dangerous and powerful villains to ever go up against Charles Xavier and his group of superheroes.

While there have been a great number of villains to do battle with the X-Men over the years, there are some that are a little more memorable, and powerful, than others. The choices on this list are villains that have mainly been associated with the X-Men branch of the Marvel universe, and does not include super powerful baddies (like, say, Thanos) that have no direct ties to the group.

Here are Screen Rant's 12 Most Powerful X-Men Villains.

12. Sabretooth

Also known as Victor Creed, Sabretooth is a mutant who was gifted with beast-like, superhuman abilities, including enhanced healing, fangs, retractable claws and supernatural senses. Having worked as an assassin and mercenary, Sabretooth takes great pleasure in killing. He made his first appearance in Iron Fist #14 (August 1977).

Although usually associated with Wolverine, Sabretooth has proven to be a formidable foe to the X-Men as well. Thanks to his animal-like abilities and his excellent hunting and tracking skills, he is very difficult to escape. He is also a master at hand to hand combat, having been trained by the likes of the CIA, HYDRA, the Foreigner and the Weapon X program. His personal relationship with Wolverine (they've even been portrayed as brothers at certain times) keeps him busy making life difficult for the X-Men.

11. Mystique

Also known as Raven Darkholme, Mystique is a powerful mutant with the ability to shapeshift. She is able to emulate any person’s physique and voice with incredible accuracy. This includes psionically shifting her cells to form clothing and other objects, such as glasses and identification tags. Her mutation also gives her cells the power of regeneration, leading to rapid healing, increased agility, immunity to diseases, and agelessness. Mystique made her first appearance in Ms. Marvel, No.16 (April 1978).

Along with her mutant abilities, Mystique is also a master of martial arts and an excellent strategist. She also has a knack for seeking out and understanding new technology and weaponry, which she uses to her every advantage. Having spent the better part of a hundred years pretending to be other people, she is able to spot others who are attempting to pose as people they are not. It’s these abilities and the fact that she’s a master of manipulation, with a penchant for languages, that make her a formidable foe.

10. Nimrod

A mutant-hunting, shape-shifting, virtually indestructible Sentinel from the Days Of Future Past timeline, Nimrod is one of the most dangerous villains in the X-Men pantheon. Able to shift his appearance to appear human, he is able to blend in with the regular population. He is also able to not only reconstruct himself, but upgrade both his physical and internal systems to maximize his potential. Brought through time by following Rachel Summers back to the present, his mandate is to destroy all mutants. Nimrod made his first appearance in Uncanny X-Men #191 (March 1985).

What makes Nimrod so powerful is the fact that he’s a robot. He can’t be reasoned with and his goal to destroy all mutants is hardwired into his circuitry. He is also able to adapt and change to counter act the abilities of the mutants that he faces, making him hard to defeat. With the ability to create energy blasts, force fields, magnetic fields and teleport, it’s easy to see why this villain is one of the most powerful in the universe.

9. The Shadow King

Also known as Amahl Farouk, this big bad is an entity made purely of psychic energy, and happens to feed off of humanity’s hatred. In order to manifest in the physical plane, he must possess a human being. He is also able to possess other beings in the astral plane, and like other high powered psychics, he is actually able to control the entire astral plane. He made his first appearance in Uncanny X-Men #117 (January 1979).

Although his origins are a little clouded (mainly due to retcon over the years), what makes The Shadow King so powerful are his psychic abilities. At one time, he was considered the second most powerful psychic, behind Charles Xavier. His ability to possess a human makes for an easy disguise, and although he is limited to the physical capabilities of his host, he has been known to tap into powers and abilities that the host doesn’t realize they have. In his natural form, only the most powerful magical weapons can harm him physically. It's these abilities, but most especially the ability to possess other psi-sensitive beings, that make him such a dangerous adversary.

8. Juggernaut

Also known as Cain Marko, Juggernaut was empowered with magical abilities when he found the Gem of the mystical entity Cyttorak and it transformed him into a super villain. His abilities include superhuman strength and extreme durability. He is also able to create a magical force field that is virtually impervious to physical attacks when it’s at its maximum strength. The step-brother to Charles Xavier in the comics, Juggernaut made his first appearance in X-Men #12 (July 1965).

Juggernaut is formidable because he doesn’t tire, heals at a rapid rate and is able to survive without food, water or oxygen. He is also physically unstoppable when he is in motion, making him difficult to defeat. It is possible, however, when his powers are used against him and he’s put in a position where he is unable to escape. While he is vulnerable to mental attacks, he circumvents this by wearing a special helmet that protects him. Nothing makes for a more dangerous foe than one with a personal vendetta, so the animosity that Marko has for Charles is all the fuel that he needs.

7. Stryfe

A clone of Nathan Summers, the son of Scott Summers and Jean Grey (well, her clone anyway), Stryfe is a mutant with telekinetic and telepathic abilities. Although he and Cable share the same abilities, he is more powerful than the original, due to the fact that he was not infected with the techno-organic virus that Cable was. Unlike Cable, his body is not forced to fight the virus, leaving his powers fully intact. Through genetic manipulation, Stryfe has enhanced his abilities to include superhuman strength and durability. He made his first appearance in The New Mutants #86 (February 1990).

Not only is Stryfe extremely powerful, but as a baby he was kidnapped and raised by Apocalypse, who thought that he was stealing the real Nathan Summers. Being raised by the biggest of the big bads in the universe, who we'll get into in a bit, certainly left a lasting impression. Stryfe is dangerous because he has all of Cable’s powers, without the limitations, or any sort of moral compass. Which just proves that even a personal code of honor is better than nothing.

6. Cassandra Nova

Cassandra is a mummudrai, a parasitic life form born bodiless on the astral plane. She became entangled with Charles Xavier’s consciousness while he was still in the womb. She essentially created herself by copying his DNA, virtually making herself his twin sister. Once he sensed her evil thoughts, he was able to kill her in the womb, making her stillborn at birth. She was somehow able to survive and managed to form a body of her own, although her thoughts and actions remained...questionable. She made her first appearance in  New X-Men #114 (July 2001).

As the polar opposite of Charles Xavier, Cassandra is also an extremely powerful telepath, though she of course uses her powers for evil instead of good. Her existence as a mummudrai gives her her own set of powers which include mental possession, astral projection and the ability to mimic others' DNA. She also has access to Charles’ latent mutant abilities, like telekinesis and the ability to phase. So, basically, she’s a more powerful, evil, Charles Xavier. Given everything, it’s easy to see why she’s considered one of the most powerful villains in the universe.

5. Mr. Sinister

Sinister is a genetically altered human, born Nathaniel Essex in Victorian London, with both superhuman physical and mental capabilities. His transformation was performed by En Sabah Nur (aka that super evil Apocalypse fella), who imbued him with telepathy, including the ability to manipulate the minds of others, and telekinetic energy projection. Mr. Sinister made his first appearance in Uncanny X-Men #221 (Sept. 1987).

A scientific genius in the fields of biology, cloning, genetics, engineering and physics, Mr. Sinister has enhanced his abilities to include control of his body at the cellular level. This has given him the ability to shape-shift and regenerate, which has given him a prolonged lifespan. His obsession with Scott Summers led him to create Madelyne Pryor (Jean's clone) leading to the birth of their son, Nathan Summers, also known as Cable. What makes Mr. Sinister so formidable, aside from his abilities, is his intelligence, which is he has used over the years to experiment on and clone other mutants in the hopes of understanding their evolution. Nothing says dangerous like a man on a mission.

4. Magneto

Surely, you saw this one coming. Erik Lehnsherr is a mutant with the ability to generate and manipulate magnetic fields. His powers work on the atomic level, which allows him to not only alter chemical structures, but also rearrange matter. While the maximum mass that he is able to manipulate is unknown, he is able to manipulate a number of objects simultaneously. Magneto is also able to generate electromagnetic pulses, as well as force-fields, which have been known to withstand extremely powerful attacks. A genius with advanced knowledge in the fields of genetic manipulation, particle physics and engineering, Magneto made his first appearance in The X-Men #1 (cover-dated Sept. 1963).

A survivor of Auschwitz, Magneto believes that, unless mutants rise up and band together against humans, they will suffer the same fate as the Jews during the Nazi regime. He does not believe that humans and mutants will ever be able to peacefully co-exist, and strives to replace homo-sapiens as the dominant species on the planet. It’s this belief that destroyed his friendship with Charles Xavier and makes him so dangerous. A zealot, one with hyper-powerful mutant abilities, makes Magneto an extremely dangerous foe.

3. Onslaught

Onslaught is a sentient psionic entity created from the consciousness of Charles Xavier and Erik Lehnsherr. When Charles is forced to use his powers to shut down Magneto, rendering the villain catatonic, the dark aspects of Magneto’s mind merged with the darkness in Charles, spawning a persona of its own and thus, creating Onslaught. Ahhh, the '90s. His abilities include telepathy, telekinesis, manipulating magnetic fields, energy projection and the ability to affect reality. He is also capable of sensing other mutants. Onslaught made his first appearance in X-Men vol. 2, #53 (June 1996).

It’s easy to see why Onslaught is considered one of the most powerful villains in the universe, given that he is basically the embodiment of the darkest aspects of two of the most powerful mutants in existence. His powers are considered well over Omega Level, making him one of the most dangerous beings ever to be introduced to the X-Men universe.

2. The Dark Phoenix

Dark Phoenix is a personification of Jean Grey of the X-Men. Brought to life when the Phoenix Force merged with Jean Grey during a mission, Dark Phoenix has the powers of telepathy and telekinesis, but to a much greater extent than Jean Grey. Also able to rearrange the molecular structure of matter and fly at supersonic speed, her abilities are somewhat incalculable; there's very few things she isn't capable of. She made her first appearance in The X-Men #129-138 (1980) in her own story arc known as the Dark Phoenix Saga, one of the most celebrated arcs in all of X-Men lore.

Dark Phoenix is beyond powerful, able to consume the power of stars. She is unstable and all about survival, making her extremely unpredictable. She is one of the most powerful mutants in the Marvel universe, and it’s only through her own sacrifice that she is able to be beaten. There is a bit of confusion as to her origins, but that doesn't stop her from being one of the most powerful foes that the X-Men have ever faced.

1. Apocalypse

Also known as En Sabah Nur, Apocalypse puts the villain in supervillain. A powerful, ancient being born with a number of superhuman abilities, which were further enhanced when he merged with Celestial technology, he is believed by many to be the first ever mutant. He is virtually immortal and indestructible, and his mutant powers give him complete control over the molecules in his body. He can change his shape and size, turn his limbs into weapons and basically give himself any superpower he wants. On top of that, he also has telepathic and telekinetic abilities and the ability to interface with technology. He made his first appearance in X-Factor #5 (May 1986).

Apocalypse is one of the main villains not only in the X-Men universe, but in the entire Marvel pantheon. His powers pretty much make a mockery of everyone else’s, and not only make him indestructible, but also nigh-immortal. He has also been known to manipulate other mutants to his cause, and there have been a number of notable characters who have taken up the mantle of one of his four horsemen. Add to that his extreme intelligence and his powers of persuasion, and you suddenly understand the horrified look in Professor Xavier's eyes from the first full-length trailer for X-Men: Apocalypse. His team of mutants may have finally bitten off more than they can chew.

Who are your favorites mutant baddies? Comment below with who you think the most powerful X-Men villains are.