Warning! Spoilers ahead for Berserk chapter 360!
One of Berserk's most pivotal scenes from the Golden Age, the one where Guts decides to leave the Band of the Hawk and Griffith, could be repeating itself in the manga.
Aside from the ramifications that Guts' exit had on Berserk's world, the moment he left shocked both readers and the Hawks profoundly. The Golden Age's foundation was built on Guts' entry into the Hawks and the change in dynamics between both Guts and Griffith was profound. Guts' abuse as a child caused him to wander aimlessly alone in the world with no purpose, which was why he initially refused Griffith's request to join the Band of the Hawks. Despite losing and accepting his fate, he came to love, respect, and defend everything the Hawks' members and their leader Griffith stood and fought for. For numerous chapters, the manga followed Guts as he fought in the name of Griffith, so when Guts eventually dueled for his freedom once more and won, everything changed.
The same could now happen with Lady Farnese who joined Guts' travels long after the Golden Age's conclusion. Although Guts has amassed quite a following since his days as the Black Swordsman, Lady Farnese's entry and transformation have been much more profound than other members. Lady Farnese was initially Guts' enemy and even served as a fanatical follower of a violent religion that condemned and sought the eradication of one of Gut's other comrades, Schierke, because she was a witch. But after meeting Guts in Berserk, Lady Farnese noticed the error in her ways, and upon joining him, she came to embrace witchcraft. Lady Farnese was a lost soul up until this moment, and although she eventually found a purpose with Guts, she seems to have found her true calling on Skellig Island. In chapter 360 of Berserk by the late mangaka Kentaro Miura, it is discovered that even though mages who begin as adults are nowhere near as capable as children mages, Lady Farnese makes an incredible achievement in mere months that normally takes children mages a year or even three years to complete.
With plans to learn many other powerful spells there, it's quite likely that Lady Farnese won't leave Skellig Island with Guts because she has found where she belongs. Although Schierke helped introduce Lady Farnese to magic, Schierke herself is only a witch-in-training and can't provide the teachings that Lady Farnese can receive on Skellig. Moreover, Lady Farnese's main purpose in Guts' troupe was protecting Casca whose near-catatonic state made her survival solely dependent on others. Now that Berserk restored Casca's mind, Lady Farnese has no one to protect. Her potential parting would be an emotional moment, almost as much as Guts' decision to leave the Band of the Hawk during the Golden Age.
Of course, it's unlikely that Lady Farnese's prospective departure would have such a profound effect on Guts as Guts' own decision to leave the Band of the Hawk did on Griffith, for Griffith had come to depend on Guts to the point where Guts' departure caused Griffith's life to unravel. Although Casca is still plagued by a severe case of PTSD, Casca is once again the self-reliant and powerful woman she once was. That said, how Guts helped Lady Farnese embrace a new philosophy on life will make her departure that much more profound and heartbreaking when Berserk finally makes its grand return.