What happened to Gamora in the aftermath of Avengers: Endgame? Zoe Saldana's popular character met her tragic end in Avengers: Infinity War, sacrificed by Thanos so he could acquire the Soul Stone on Vormir. Her death devastated the Guardians of the Galaxy, with Star-Lord losing it in a key moment and costing the heroes a possible victory in their battle against Thanos on Titan.
But Avengers: Endgame reintroduced Gamora through the conceit of time travel. The film saw the Avengers return to the opening scenes of the first Guardians of the Galaxy film in 2014, where they unwittingly found themselves in Thanos' crosshairs. The Mad Titan and his agents pursued the Avengers forward in time, emerging in 2023 and laying waste to the Avengers Compound. Fortunately for the Avengers, Nebula was able to persuade the 2014 Gamora to switch sides - a neat inversion of her plot in Guardians of the Galaxy Vol. 2. When Tony Stark snapped his fingers in his Mark 85 suit embedded with the Infinity Stones, Thanos and everyone who was loyal to him crumbled to dust.
But Gamora's Avengers: Endgame fate was unseen. Was she affected by Stark's snap as well? Or had her decision to side with the Avengers saved her life? She wasn't shown returning to her own time, but neither was she shown alongside the survivors in the aftermath of Thanos' defeat.
The key consideration is probably Guardians of the Galaxy Vol. 3. James Gunn is back on board for that project, and he's already confirmed that Saldana will have a significant role in it. Avengers: Endgame ended with Thor joining the Guardians and, before the God of Thunder challenged Star-Lord's captaincy of the Benatar, Peter was shown looking for information on Gamora.
It's possible that Quill wants to find a way to bring Gamora back from her death in Avengers: Infinity War, although that may prove tricky; the Hulk confirmed that even the power of the Infinity Gauntlet can't bring back someone who's been sacrificed to the Soul Stone, as he tried to do just that with Black Widow. It's true that, in the comics, some characters have successfully escaped the Soul World inside the Soul Stone where it was theorized Gamora was sent. However, that was at the cost of part of their own soul and, in the MCU, Thanos destroyed the Soul Stone, making such a move tricky.
While bringing Gamora back would be interesting, the more logical conclusion is that Gunn was referring to the Gamora of this 2014 timeline, who has been brought back to the present - and presumably survived the decimation of Thanos' troops. It's worth remembering that Gunn himself wrote dialogue for the Guardians in Avengers: Infinity War and presumably also in Avengers: Endgame, so he knew exactly what was being set up.
It would certainly be fascinating to see how Peter Quill and the rest of the Guardians of the Galaxy cope with this new/old Gamora. As teased in Avengers: Endgame when Star-Lord reached out and touched Gamora's face, he'll long to resume their relationship; but Gamora doesn't look to want anything to do with him, once again considering him an idiot. The very fact that Gamora seems to have disappeared suggests that she wants to blaze her own trail, and Peter may need to deal with the heartbreaking reality that the Gamora who loved him is truly gone.
One tie does remain between this new/old Gamora and the Guardians of the Galaxy, though. Beneath all the anger and fury, she still seems to care deeply about Nebula, to the extent that her sister was able to persuade her to change sides. Avengers: Endgame saw both Nebula and Thor join the Guardians of the Galaxy - or the Asgardians of the Galaxy, as Thor called them - and that means Gamora will still want to work alongside the team.