The FX Alien TV show's timeline makes a potentially fascinating Prometheus connection possible for the series. Written by Fargo's Noah Hawley, Alien tells the story of a near-future Earth some 30 years before Ripley and the Nostromo crew's fateful voyage that began in 2120. According to FX chief John Landgraf, the Alien prequel series takes place "70-odd years from now" (per Esquire), placing it at the center of some of the Alien franchise's most fascinating lore and history.
Landgraf's comments root FX's Alien show in 2092, the same year Sigourney Weaver's Ellen Ripley is born on a near-future Earth. This overlap in the Alien canon is clearly no fluke by the Alien prequel series, indicating Hawley and company's sincere desire to pay homage to Ridley Scott's seminal original movie. While Ripley is confirmed not to feature at all in FX's Alien story, Hawley has confirmed the show will instead take a closer look at the shady Weyland-Yutani corporation, placing an added emphasis on the corporate raiders dispatching doomed crews (just like the Nostromo's) into space.
As a result, FX's Alien show timeline makes a connection to Prometheus not only possible but plausible too. The Alien prequel series' plans indicate a significant amount of symmetry with Prometheus' narrative, with the USCSS Prometheus leaving Earth just one year before FX's Alien begins chronologically. In this way, the bulk of Prometheus' events will occur during the Alien series' timeline of events - making Weyland-Yutani's reaction to the horrors unfolding on LV-223 a likely subplot for the show.
The 2090s in which Alien's prequel show takes place is a monumental decade in the Alien canon. As aforementioned, the USCSS Prometheus, a space exploration ship built by Weyland Corp, leaves Earth on its journey to LV-223 in 2091. Just two years later, in 2093, the harrowing events depicted in Prometheus see all but two of the USCSS Prometheus crew killed after an encounter on LV-223 with an alien species and a revived Engineer. Their ship is subsequently destroyed, forcing Dr. Shaw (Close's Noomi Rapace) and a severely damaged David (Michael Fassbender) to leave on an Engineer ship to find the Engineers' homeworld. Following this, according to David's testimony in Alien: Covenant, Shaw rebuilds David before the pair arrive at the Engineer planet "Paradise" and commit genocide, killing its inhabitants with the tar-payload aboard their vessel.
With these massive events in mind, including the birth of the first Xenomorph on LV-223, FX's Alien will likely cover these events through the eyes of Weyland-Yutani. It would be strange for the company responsible for dispatching the USCSS Prometheus not to react to the cataclysmic events happening indirectly by their hand, setting up an engrossing narrative as they set about performing damage limitation on Earth. Furthermore, the Alien TV series may be able to add additional context to David's origins, with Peter Weyland building the android in 2030 and charging him with his covert mission in Prometheus between 2088 and 2091. As a result, the Alien show's timeline makes a tantalizing Prometheus connection possible that can enrich the lore surrounding Ridley Scott's prequel movies.