While you probably couldn’t tell from the few scenes that she was a part of in the film, the messiah-like cult leader Lady Miyako actually had a decent role to play in the events of the manga. The Lady Miyako of the manga is yet another child the government of
Japan experimented on after granting her immense psychic abilities. While she managed to escape the government facility others like Tetsuo are taken to and experimented on, she fights to expose the government's experiments and the effects they’ve had on her. Much like the Colonel Shikishima, she is one of the few people in the manga looking out for the people of Japan. She even helps train Kei to fight off Tetsuo during the climax of the manga.