The Sixth Race Of The Confederacy
The villains of Agents of S.H.I.E.L.D. season 5 were an alien Confederacy, a thousand-year-old alliance between different groups who plunder resources from other worlds and trade with one another. They included the Kree outcast faction House Kasius, the shadow-warrior race called the Remorath, the brutal Rajaks, a possibly-nomadic race called the Kallusians, and the metal-manipulating Astrans. It's possible the Confederacy aren't done with Earth; certainly the Rajaks may want revenge given Graviton killed their leader.
But here's the catch: Agents of S.H.I.E.L.D. revealed that there's a sixth member of the Confederacy, but didn't identify who those aliens are. That's led many to speculate that the sixth race in the Confederacy is intended to be the Skrulls, but that the show didn't have permission to use them until after Captain Marvel. If that's the case, the S.H.I.E.L.D. crew could be facing a terrifying and dangerous new threat.
What Will Happen To Deke?
Jeff Ward has been promoted to a series regular for Agents of S.H.I.E.L.D. season 6, which means the time-traveling Deke is sure to be important in some way. Deke originates from a now-averted future timeline in which the Earth was shattered like an egg, and he was last seen heading off to enjoy the Earth. How will he team up with S.H.I.E.L.D. again, and will Deke's unrequited love for Quake ultimately mean he gets a shot at romance?
The Mystery Of Vijay Nadeer
Season 4 introduced viewers to Vijay Nadeer, the brother of an anti-Inhuman senator who unfortunately possessed an Inhuman gene. Exposed to Terrigen, he underwent an unusually gradual form of Terrigenesis, and emerged from a cocoon with some sort of combat instincts and enhanced reflexes. Vijay was shot by his sister, and his body was dumped into the ocean; curiously, trace elements of Terrigen in the water triggered secondary Terrigenesis, and a new cocoon formed around Vijay's body. The idea of secondary Terrigenesis was revisited by Marvel's Inhumans series, which revealed that it damages the Inhuman's mind. Vijay hasn't been seen since Agents of S.H.I.E.L.D. season 4, so he's surely overdue to return.
Could The Ghost Rider Return?
Of course, there's one character from Agents of S.H.I.E.L.D. season 4 who every fan wants to see return; Gabriel Luna's Ghost Rider. Luna played Robbie Reyes, a car mechanic from Los Angeles who became host to the Spirit of Vengeance, and he proved to be an absolute hit. The special effects were stunning, although they proved too expensive to keep the character for the full 22 episodes. Season 4 ended with Ghost Rider taking possession of the Darkhold, using his chain to open a portal, and stepping through it. He's not been seen since - but there's a huge appetite for the Ghost Rider's return.
How Is Agent Davis Still Alive?
Played by Max Osinski, Agent Davis has been a recurring secondary member of the S.H.I.E.L.D. team - introduced all the way back in season 1. His fate appeared to be sealed during season 4, when he turned his back on Aida, failing to realize she was still alive. Davis curiously survived an encounter with the psychopathic ex-android, though, apparently walking away with only a scar. Agents of S.H.I.E.L.D. has never explained what happened, but Davis quite enjoys telling the story - and it's a rather spectacular one, prompting an astonished reaction from Deke.
But is it true? After all, Davis apparently survived an encounter with a powerful being known for creating android doppelgangers of S.H.I.E.L.D. agents. What's more, the show exists in a cinematic universe where there are at least two races of shapeshifters, the Skrulls and the Xartans (introduced in Runaways). Many fans believe that all is not as it seems, and that Davis was really killed by Aida - and replaced. Interestingly enough, Davis is the only cast member confirmed to be appearing throughout season 6 on IMDb. So this mystery may well be resolved.