Marvel's Agents of S.H.I.E.L.D.'s 100th episode featured a long-awaited wedding and a few callbacks and guest stars that harkened all the way back to the very first episode where it all began. Episode 100, titled "The Real Deal", saw the welcome return of J. August Richards as Mike Peterson, a.k.a. Deathlok, while manifestations of Inhuman villains Lash and Hive, and even some Vrellnexian roaches, tried to stop Agent Phil Coulson from sealing a dimensional rift to a fear dimension and saving the world.

Sadly, not everyone in the series' storied history could make it to this party. Even with the walks down memory lane "The Real Deal" had in store for its longtime fans to ring in this milestone, a mere hour couldn't possibly squeeze in all of the characters fans wished they could have seen again.

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While Agents of S.H.I.E.L.D. has featured dozens and dozens of characters in its 100 hours of TV thus far, here are the major names that unfortunately didn't or couldn't appear in the centennial episode:

S.H.I.E.L.D.

bobbi morse lance hunter agents of shield

Bobbi Morse and Lance Hunter received a memorable "spy's goodbye" as a sendoff midway through season 3, though Hunter did just make a comeback to help Fitz get to the future in the season 5 episode "Rewind." Other major names who have fought for S.H.I.E.L.D. but didn't make the 100th episode are Billy, Sam and Thurston Koenig (all played by Patton Oswalt). Their brother Eric Koenig is dead, as is former S.H.I.E.L.D. Director Jeffrey Mace. It would also have been nice to see Antoine "Tripp" Triplett again, but an avatar of him was in season 4's Framework. General Glenn Talbot, a frequent thorn in S.H.I.E.L.D.'s side, hasn't been seen since a Life Model Decoy of Daisy Johnson shot him in season 4.

HYDRA

Unfortunately, Brett Dalton didn't return to play Hive in "The Real Deal", but the traitorous Grant Ward - arguably the series' most memorable villain - was seen in "The Real Deal" in Coulson's blink-and-you'll-miss-it flash-cuts! The other major names from HYDRA like Daniel Whitehall and Sunil Bakshi are also dead in the series, as are Ward's mentor John Garrett and Gideon Malick. Sadly, the actors who portray Garrett and Malick, Bill Paxton and Powers Booth, both died in 2017.

Inhumans

Agents of S.H.I.E.L.D. introduced the Inhumans to the MCU. Besides Daisy Johnson and Yo-Yo Rodriguez, fear dimension-conjured versions of Lash and Hive represented the Inhumans in the 100th episode. Raina, the Girl in the Flower Dress, May's husband Dr. Andrew Garner (who was Lash's human alter ego), Daisy's lightning-powered boyfriend Lincoln Campbell, and her mother Jianying are all dead. Daisy's father Calvin Zabo, aka Mr. Hyde, wasn't seen or referenced in episode 100.

Related: Agents of S.H.I.E.L.D. Confirms A Major FitzSimmons Fan Theory

The Framework

Season 4 was broken up into story pods, the first involving Robbie Reyes and his demonic alter ego Ghost Rider. The Spirit of Vengeance's deal with Coulson was referenced in "The Real Deal", but the Rider himself was nowhere to be seen. Nor were the true villains of the fourth season, Dr. Holden Radcliffe and his malevolent creation Aida, who in turn created the Framework and tried to subsume reality itself with it.

The Lighthouse In The Future

Kasius with Sinara in Agents of SHIELD

Season 5's Kree villains from when the Agents time traveled to the future are among the series' finest, but it's not unexpected that Kasius and Sinara were absent from "The Real Deal" (although Sinara was referenced last week when Daisy assumed the alias of social worker 'Sinara Smith'). Also left behind in the future are the Agents' newest allies Tess and the Inhuman Flint.

While she made quite a debut by butchering Yo-Yo's arms in last week's episode, Agents of S.H.I.E.L.D.'s newest villain Ruby also sat out the 100th episode, despite an appearance by her mother General Hale. But last week's episode certainly won't be the last fans see of Ruby.

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Marvel's Agents of S.H.I.E.L.D. airs Fridays @ 9 pm on ABC.