15Hurt: Shannen Doherty and Alyssa Milano
Charmed fans may be freaking out over the reboot (for better or worse), but this was the original TV bomb back in the day. Shannen Doherty and Alyssa Milano played sisters Prue and Phoebe Halliwell in the original series. Behind the scenes, however, things weren’t as sisterly. It led to Doherty’s
character being killed off at the end of season three. This seemed to be the final nail in the coffin as Doherty had a reputation for being difficult to work with. She never quite enjoyed the same level of fame that she once had. Milano, meanwhile, played Phoebe until the show went off the air and was popular with fans.
Things have been better in recent years, though. The pair apparently reconnected and rebuilt bridges as Doherty battled breast cancer. In 2017, Doherty's cancer went into remission.