The wait is nearly over for Vincenzo Natali’s sci-fi horror film Splice – about two scientists who create a new being by mixing together genetic material from humans, kangaroos, birds, and other living organisms.

As we’ve seen from the previous trailers, the result is not pretty.

Optimum Releasing, the international distributor for Splice, has supplied us with another glimpse at the highly-anticipated film. The trailer contains mild spoilers – featuring Dren, the Splice creation, in her later stages of development.

Check out the trailer after the jump – but don’t say we didn’t warn you:

The new trailer definitely focuses a bit more on the horror aspect of the sci-fi horror hybrid – though, I’m personally hoping the film keeps a healthy balance between the two. The earlier trailers were both disturbing and strangely charming – a mixture that will be extremely important in the final product.

Should the film be too heavy on the horror aspect, I think it’ll lose some of the magic inherent in the film’s premise – which is essentially grounded in both the glory and fallout of scientific discovery. A lot of big budget action-horrors tend to focus a lot on the disaster that comes after pushing the boundaries of science – without spending much time reveling in the joy of the creative process.

The Species films, which Splice is often compared to, shared the same basic notion: human DNA + non-human DNA = trouble. While Species was certainly an entertaining ride, in the end, its monster lacked the most interesting aspect of humanity – a conscience.

I’ve still got my fingers crossed that Splice will do a better job of harnessing the humanity in Dren – if for no other reason than to shatter that humanity to bits by the end.

What do you think of the new Splice trailer? What would you like to see in the final film?

Splice is set for a June 4, 2010 release.

Source: Row Three and Bloody Disgusting