Pirates of the Caribbean trilogy director Gore Verbinski reunited with Johnny Depp for the upcoming computer-animated feature Rango, and unlike most every other non-DreamWorks or Pixar toon that will hit theaters this year, it looks to be something both unique and memorable.

A couple of clips from the movie have been circling the Web recently, and both offer a taste of Rango‘s refreshingly off-beat humor – as well as its use of some genuinely amusing cartoonish physical comedy.

Depp provides the voice of Rango, a chameleon who longs to become a daredevil hero (and who kind of looks like the reptilian version of Depp in Fear and Loathing in Las Vegas). When the domesticated lizard is unexpectedly stranded in the desert, he finds his way to a small Western town that is populated by local critters and plagued by a group of bandits led by the vicious Rattlesnake Jake (Bill Nighy). It’s there that Rango becomes the swashbuckling hero he always wanted to be.

Those who saw the first Rango trailer likely recall that it focused primarily on introducing the movie’s namesake, who finds himself pursued relentlessly by a hungry hawk under the hot blazing sun. That’s also the case in this first clip, which throws a convenient glass bottle and cranky horned toad into the mix as well.

Check it out below:

Eventually Rango gets to throw on some cowboy gear and lead his fellow desert-dwellers on an adventure across the sparse terrain. As illustrated by this next scene (and in the full-length trailer for Rango), the movie pokes fun at numerous clichés of the western genre, including the stereotypical guitar-heavy musical soundtrack.

Watch the clip below:

Rango marks the first fully-animated effort from Industrial Light & Magic, and the company looks to have created some impressively photorealistic animals who are still distinctly cartoonish in design. The filmmakers’ use of the “natural acting” creative process also looks to have paid off, since the characters’ movements appear all the more fluid and believable. Add to that the fact that this is one CGI pic that may entertain both kids and older moviegoers, and that’s all the more reason to be excited for its release.

Rango arrives in theaters on March 4th, 2011.

Source: Hulu and Yahoo! Movies