Seth MacFarlane is no stranger to voice acting, but it’s rare to see him in live-action roles. One thing that MacFarlane’s planned comedy-Western, A Million Ways to Die in the West, has going for it is that it will finally see the Family Guy creator take center stage in a live-action feature lead role for the first time.

MacFarlane will play a wimpy sheep farmer who finds himself abandoned by his girlfriend after he backs out of a pistol duel, but then finds his life and courage rejuvenated by the arrival of a mysterious and beautiful stranger…and the subsequent arrival of her very angry outlaw husband.

We’ve been writing up casting snippets for the film- which recently got a spring 2014 release date – for some time now, but a new statement released by Universal Pictures and published over at Slash Film lists the full central cast. Along with the previously announced Charlize Theron, Amanda Seyfried, Liam Neeson and Giovanni Ribisi, the list includes Neil Patrick Harris and Sarah Silverman.

MacFarlane’s feature directorial debut, Ted, was a resounding success, especially for an R rated comedy, pulling in ten times its original production budget at the worldwide box office. The writer, director and actor has a large and dedicated following thanks to his work as the creator of Family Guy and co-creator of sister series The Cleveland Show and American Dad, but he’s also a talent that tends to be a little divisive, with people often either loving him or hating him.

Neil Patrick Harris, on the other hand, seems to be one of those actors who’s loved by all. Known for starring in the sitcom How I Met Your Mother and alongside Felicia Day and Nathan Fillion in Joss Whedon’s musical miniseries Dr. Horrible’s Sing-Along Blog, Harris has also made brief cameo appearances (as Barney Stinson) on Family Guy. Straddling the line as he does between mainstream popularity and niche geek appeal, Harris’ attachment to MacFarlane’s new comedy will probably pull in quite a few dedicated fans.

The other new name included in the press release is Sarah Silverman, a veteran comedienne who created, starred in and lent her name to Comedy Central’s The Sarah Silverman Program – which ran for three short seasons before being canceled – and also voiced Vanellope in Disney’s recent love letter to old-school arcade games, Wreck-It Ralph.

Are Harris and Silverman enough to entice you to watch A Million Ways to Die in the West, or were you planning to see it as soon as you heard the name “MacFarlane”? Share your thoughts on this latest casting news in the comments.

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A Million Ways to Die in the West will be released theatrically on May 30th, 2014.

Source: Slash Film