Director John Landis (An American Werewolf in London) has been keeping a low profile since his poorly-received sequel Blues Brothers 2000 hit theaters back in 1998. Now he is back with Burke and Hare, a dark comedy that the newly-released UK trailer not-so-subtly alludes to being “the ultimate crowd-pleaser.”

Burke and Hare features a well-to-do cast that includes Star Trek‘s Simon Pegg, Andy Serkis (Lord of the Rings) and Isla Fisher (Wedding Crashers), along with the likes of Tom Wilkinson, Tim Curry, and Christopher Lee. Piers Ashworth and Nick Moorcroft scripted the film, which hits UK theaters near the end of this month.

The plot revolves around a pair of Irishmen – one William Burke (Pegg) and William Hare (Serkis) – who struggle to make a living in 19th century Edinburgh. The two soon discover they can turn a nice profit by delivering fresh cadavers to the unethical Dr. Knox (Wilkinson) at a local medical school. Wacky antics that involve difficult-to-maneuver corpses, the Edinburgh militia, and a lovely “actress” named Ginny (Fisher) ensue soon thereafter.

Dark comedy can be a tricky act to pull off since it generally deals with some fairly macabre subject matter. The trailer for Burke and Hare plays up the broader comedic aspects of the film, which looks to feature plenty of gross-out gags that involve dead bodies and the like – depending on their preferences, moviegoers might find it all hilarious or a bit much, like something out of a gruesome sitcom.

Check out the UK trailer for Burke and Hare below:

A number of the jokes on display in the Burke and Hare trailer are way too familiar and fail to play out in a way that feels fresh or inventive. This might be a case where the film’s best bits of humor are R-Rated and cannot be shown in a preview for general audiences, but the footage that is on display doesn’t exactly inspire a whole lot of confidence.

Burke and Hare looks like it could have some funny moments, courtesy of Pegg and Serkis, and it has the look of a professional production with some nice, shadowy lighting and set design. The movie has yet to secure a U.S. release date, but it could be worth a look when it finally does make the journey over here to the states.

Burke and Hare hits UK theaters on October 29th, 2010.